中国现代医学杂志2017，Vol.27Issue(29)：16-20,5.DOI:10.3969/j.issn.1005-8982.2017.29.004
万古霉素单用及联合用药对MRSA耐药性的影响
Effect of single use and combined use of Vancomycin on drug resistance of MRSA
翟蕙 1李家斌1
作者信息
- 1. 安徽医科大学第一附属医院 感染科,安徽 合肥 230022
- 折叠
摘要
Abstract
Objective To culture the clinical isolates of Methicillin-resistant Staphylococcus aureus (MRSA) and compare the efficacy of single and combined use of Vancomycin against MRSA infection. Methods Agar dilution method was applied to confect broth culture medium, which was used to culture 1×1010 CFU/ml concentration of bacteria. The mutant prevention concentrations of single and combined use of Vancomycin for 10 clinical isolates of MRSA were determined, and then the corresponding selection index and the frequency of drug resistance were calculated. Results For the 10 MRSA isolates, the selection indexes of Vancomycin used alone were 16-64, the selection indexes of Vancomycin combined with Rifampicin were 2-6, and the selection indexes of Vancomycin combined with Fosfomycin were 1-8; meanwhile the frequency of drug resistance showed a downward trend. Conclusions Compared to single use, Vancomycin combined with Rifampin or Fosfomycin can reduce the mutant prevention concentration for MRSA, and narrow the drug-resistant mutant selection window, and prevent the production of drug-resistant mutant bacteria.关键词
耐甲氧西林金黄色葡萄球菌/万古霉素/联合用药/防耐药突变浓度/耐药突变选择窗/耐药频率Key words
Methicillin-resistant Staphylococcus aureus/Vancomycin/drug combination/mutant prevention concentration/drug-resistant mutant selection window/frequency of drug resistance分类
医药卫生引用本文复制引用
翟蕙,李家斌..万古霉素单用及联合用药对MRSA耐药性的影响[J].中国现代医学杂志,2017,27(29):16-20,5.
