中国现代医学杂志2017，Vol.27Issue(29)：21-24,4.DOI:10.3969/j.issn.1005-8982.2017.29.005
甲氨蝶呤/蒙脱土插层药物的缓释作用研究
Study on sustained release effect of Methotrexate/Montmorillonite intercalation drugs
安丰田 1朱文静 1初晓1
作者信息
- 1. 山东省青岛市立医院 药剂科,山东 青岛 266000
- 折叠
摘要
Abstract
Objective To investigate whether Methotrexate/Montmorillonite intercalation drugs (MTX/MMT release system) can be used as drug delivery agents in clinic. Methods MTX/MMT release system was prepared by solution intercalation technique. The experiment adopted UV, FT-IR and other means to characterize the structural characteristics. Through simulation of gastric and intestinal fluid release experiments in vitro, the releasing rules and intrinsic mechanism of sustained-release delivery system were investigated. The initial drug concentration, reaction time, reaction pH value and reaction temperature on the MMT drug loading were explored. Results The maximum amount of drug intercalation was obtained at the initial concentration of 0.8804 μg/ml, pH 1 and 50℃ for 4 hours. In the in vitro release experiment, sustained release of the MTX/MMT release system was observed in the simulated gastric and intestinal fluid, but the amount of release was smaller and the release speed was slower in the simulated gastric fluid. Conclusions Methotrexate/Montmorillonite intercalation drugs may be used as drug delivery agents in clinic.关键词
溶液插层法/蒙脱土/甲氨蝶呤/恒温超声法/紫外分光光度法Key words
solution intercalation method/Montmorillonite/Methotrexate/constant temperature ultrasonic method/UV spectrophotometry分类
医药卫生引用本文复制引用
安丰田,朱文静,初晓..甲氨蝶呤/蒙脱土插层药物的缓释作用研究[J].中国现代医学杂志,2017,27(29):21-24,4.
