中国现代医学杂志2017，Vol.27Issue(29)：25-31,7.DOI:10.3969/j.issn.1005-8982.2017.29.006
鼻咽癌肿瘤组织中IgM的表达及其临床意义
Expression of IgM and its significance in human nasopharyngeal carcinoma tissues
摘要
Abstract
Objective To detect the expression of IgM in nasopharyngeal carcinoma (NPC) tissues, and to explore its relationships with the clinicopathological characteristics and prognosis of NPC patients. Methods Immunohistochemical streptavidin-biotin-peroxidase complex (SABC) method was used to detect the expression of IgM in the NPC tissues of 92 patients, the pathologically-diagnosed nasopharyngeal inflammatory tissues of 50 cases were taken as controls. The results were analyzed in combination with clinical and pathological data and prognosis of the NPC patients. Results The positive expression rate of IgM in the NPC tissues was 68.48%, which was significantly higher than 24.00% of the nasopharyngeal inflammatory tissues (P < 0.05). The expression of IgM was mainly located in the cytoplasm in the NPC tissues, but in the cell membrane of the nasopharyngeal inflammatory tissues; and the cytoplasm expression mostly appeared in poorly-differentiated squamous cell carcinoma, and the cell membrane expression was mainly observed in the moderately- and well-differentiated NPC and the nasopharyngeal inflammatory tissues. The expression of IgM in the NPC tissues was negatively correlated with T stage and clinical stage (P < 0.05) in the patients with NPC and had nothing to do with local or cervical recurrence or distant metastasis (P > 0.05). The overall survival rate of the NPC patients with positive IgM expression was significantly higher than that of the NPC patients with negative IgM expression (57.14% vs. 27.59%, P < 0.05), but the disease-free survival rate was not significantly different between the positive IgM expression group and the negative group (P > 0.05). Conclusions IgM is highly expressed in NPC. It is necessary to further study whether the different expression sites of IgM in NPC and different degree of differentiation are related to the function of the protein. The high expression of IgM may be involved in the early pathogenesis of NPC and can be used as an useful indicator for prognosis prediction of NPC patients.关键词
鼻咽癌/免疫球蛋白M/免疫组织化学法Key words
nasopharyngeal carcinoma/immunoglobulin M/immunohistochemistry分类
医药卫生引用本文复制引用
许胜恩,徐伟,赵飞鹏,杨金亮,梁传余,覃纲..鼻咽癌肿瘤组织中IgM的表达及其临床意义[J].中国现代医学杂志,2017,27(29):25-31,7.基金项目
四川省泸州市人民政府 - 四川医科大学科技战略合作项目 [No :2015LZCYD-S02(4/11)] （4/11）
