中国现代医学杂志2017，Vol.27Issue(29)：39-44,6.DOI:10.3969/j.issn.1005-8982.2017.29.008
宫颈癌组织中CDK8、p53、VEGF表达水平与肿瘤血管生成的关系研究
Expressions of CDK8, p53 and VEGF in cervical cancer and their correlations with angiogenesis
薛宏 1汪光慧 1李勇 2卜兴江3
作者信息
- 1. 安徽省芜湖市第二人民医院妇科,安徽 芜湖 241000
- 2. 安徽省芜湖市第二人民医院病理科,安徽 芜湖 241000
- 3. 安徽师范大学生命科学学院,安徽 芜湖 241000
- 折叠
摘要
Abstract
Objective To investigate the expressions of cyclin-dependent kinase 8 (CDK8), p53 and vascular endothelial growth factor (VEGF) in the cervical cancer tissues and their correlations with tumor angiogenesis. Methods Sixty cervical cancer patients were collected in our hospital. And the CDK8, p53, VEGF and microvessel density (MVD) in the cervical cancer tissues were detected. The correlations of CDK8, p53, VEGF and MVD with the main clinical features of cervical cancer were studied. Results MVD of the VEGF-positive patients was higher than that of the VEGF-negative patients (P < 0.05); MVD of the CDK8-positive patients was higher than that of the CDK8-negative patients (P < 0.05); there was no significant difference in MVD between the patients with negative p53 and those with positive p53 (P > 0.05). Compared with the adjacent tissues, VEGF(+), CDK8(+) and p53(+) rates and MVD were significantly increased in the cervical cancer tissues (P < 0.05). Compared with the patients of International Federation of Gynecology and Obstetrics (FIGO) stage I, the patients of FIGO stage II-IV got increased VEGF(+), CDK8(+) and p53(+) rates and MVD (P < 0.05). When compared with the patients with highly-differentiated carcinoma, the patients with moderately- or poorly-differentiated carcinoma got a higher CDK8(+) rate (P < 0.05). Compared with the squamous carcinoma patients, the patients with adenocarcinoma got a higher VEGF(+) rate and increased MVD (P < 0.05). Multiple linear regression analysis showed that VEGF and CDK8 were the factors influencing MVD in the cervical cancer tissues (P < 0.05). Conclusions The expression levels of CDK8, VEGF and p53 are elevated in cervical cancer tissues, which can promote the growth and metastasis of tumor cells. And CDK8 and VEGF may be related to tumor angiogenesis.关键词
宫颈癌/血管内皮生长因子/细胞周期依赖性蛋白激酶8/微血管密度/p53Key words
cervical cancer/vascular endothelial growth factor/cyclin-dependent kinase 8/microvessel density/p53分类
医药卫生引用本文复制引用
薛宏,汪光慧,李勇,卜兴江..宫颈癌组织中CDK8、p53、VEGF表达水平与肿瘤血管生成的关系研究[J].中国现代医学杂志,2017,27(29):39-44,6.
