中国现代医学杂志2017，Vol.27Issue(29)：71-75,5.DOI:10.3969/j.issn.1005-8982.2017.29.015
T2DM患者血浆Gas6、Omentin-1与IR、肥胖及脂代谢的相关性分析
Correlations of serum Gas6 and Omentin-1 with insulin resistance and lipid metabolism in type 2 diabetes patients
摘要
Abstract
Objective To investigate plasma growth arrest-specific 6 (Gas6) and Omentin-1 levels of type 2 diabetes patients and to explore the relationships of plasma Gas6 and Omentin-1 levels with insulin resistance (IR), obesity and lipid metabolism. Methods The fasting plasma levels of Omentin-1 and Gas6 were detected by enzyme-linked immunosorbent assay (ELISA) in 40 T2DM patients with overweight obesity (BMI ≥ 25 kg/m2), 50 T2DM patients with normal weight and 30 normal controls. Meanwhile, data including fasting insulin (Fins), blood glucose and blood lipids were also obtained. The correlations of plasma Gas6 and Omentin-1 levels with those indicators were analyzed. Results Compared with the normal control group, the plasma levels of Gas6 and Omentin-1 were lower in the type 2 diabetes patients (P < 0.05). The plasma Gas6 and Omentin-1 levels of the overweight obesity group were significantly lower than those in the normal weight group and the normal control group (P < 0.05). The serum Gas6 and Omentin-1 levels were positively correlated with HDL-C (P < 0.05), but negatively correlated with HOMA-IR,BMI, TG, TC and LDL-C (P < 0.05). Conclusions The levels of plasma Gas6 and Omentin-1 are associated with insulin resistance, obesity and lipid metabolism, which may contribute to the pathogenesis of type 2 diabetes.关键词
2型糖尿病/生长停滞特异性蛋白/网膜素-1/胰岛素抵抗Key words
type 2 diabetes/Gas6/Omentin-1/insulin resistance分类
医药卫生引用本文复制引用
杨玉红,潘佳秋,徐静波,于学静,张超..T2DM患者血浆Gas6、Omentin-1与IR、肥胖及脂代谢的相关性分析[J].中国现代医学杂志,2017,27(29):71-75,5.基金项目
佳木斯大学科学技术校级面上项目(No :S2013-044) （No :S2013-044）
