中国药房2017，Vol.28Issue(34)：4808-4811,4.DOI:10.6039/j.issn.1001-0408.2017.34.14
缬沙坦胶囊灌胃给药后在兔眼组织的分布规律研究
Study on the Distribution Law of Valsartan Capsules in the Ocular Tissue of Rabbit Eyes after Intragastri-cal Administration
摘要
Abstract
OBJECTIVE:To study the distribution law of Valsartan capsules in the ocular tissue of rabbit eyes after intragastri-cal administration. METHODS:3 rabbits(6 eyes)were intragastrically administrated Valsartan solution,7.5 mg every time,twice a day,for 6 d. Rabbits were executed after last administration,and the cornea,iris,aqueous humor,lens,vitreous and retina tis-sues were collected. HPLC was used to determine the content of valsartan in each tissue. RESULTS:Content of valsartan in retina, iris,cornea,aqueous humor,vitreous and lens were (4.274 ± 1.75),(2.233 ± 0.72),(0.871 ± 0.66),(0.713 ± 0.49),(0.177 ± 0.07),(0.083 ± 0.06)μg/g,respectively. CONCLUSIONS:After multiple administrations,valsartan distributes unevenly in each tissue of eyes,showing highest distribution content in retina,followed by iris,and lowest content in lens and vitreous.关键词
缬沙坦/高效液相色谱法/眼组织/兔/分布Key words
Valsartan/HPLC/Ocular tissue/Rabbit/Distribution分类
医药卫生引用本文复制引用
李志金,李静,张越,杨赞章..缬沙坦胶囊灌胃给药后在兔眼组织的分布规律研究[J].中国药房,2017,28(34):4808-4811,4.基金项目
邢台市科技计划项目(No. 201422048-1) （No. 201422048-1）
