中国药房2017，Vol.28Issue(34)：4864-4867,4.DOI:10.6039/j.issn.1001-0408.2017.34.29
HP-β-CD对辛夷挥发油中桉油精溶解度的影响及辛芷滴鼻剂提取工艺研究
Effect of HP-β-CD on Solubility of 1,8-Oxido-p-menthane in Volatile Oil of Magnoliae Flos and Study on the Extraction Technology of Xinzhi Nasal Drops
摘要
Abstract
OBJECTIVE:To study the effect of HP-β-CD on solubility of 1,8-oxido-p-menthane in volatile oil of magnoliae flos,and optimize the extraction technology of Xinzhi nasal drops. METHODS:Steam distillation method was adopted to extract the volatile oil in magnoliae flos. Using the content of 1,8-oxido-p-menthane in volatile oil of magnoliae flos as index,HPLC was adopted to determine the effects of HP-β-CD with different concentration on solubility of 1,8-oxido-p-menthane in volatile oil of magnoliae flos. Using the comprehensive scores of imperatorin and extract yield as indexes,orthogonal test was used to optimize the amount of ethanol,volume fraction and extraction time in extraction technology of Xinzhi nasal drops. Verification test was car-ried out. RESULTS:50% HP-β-CD aqueous solution can improve the solubility of 1,8-oxido-p-menthane to 7.6 times. The optimal extraction technology of Xinzhi nasal drops was as follow as 10-fold 80% ethanol,extracting twice,1 h every time. In verification test,the average content of imperatorin was 0.078%(RSD=2.01%,n=3),and extract yield was 10.80%(RSD=1.85%,n=3). CONCLUSIONS:HP-β-CD shows good solubilization effect on the 1,8-oxido-p-menthane in volatile oil of magnoliae flos,and the optimized extration technology for Xinzhi nasal drops is feasible.关键词
辛夷/桉油精/欧前胡素/滴鼻剂/2-羟丙基-β-环糊精Key words
Magnoliae flos/1/8-Oxido-p-menthane/Imperatorin/Nasal drops/2-hydroxypropyl-β-cyclodextrin分类
医药卫生引用本文复制引用
库德热提·阿吉,赵媛,杨继彪,刘艺,许忠..HP-β-CD对辛夷挥发油中桉油精溶解度的影响及辛芷滴鼻剂提取工艺研究[J].中国药房,2017,28(34):4864-4867,4.基金项目
乌鲁木齐市卫生局科学技术计划项目(No.201428) （No.201428）
