中国药房2017，Vol.28Issue(34)：4876-4878,3.DOI:10.6039/j.issn.1001-0408.2017.34.32
盐酸鲁拉西酮固体分散体的制备、表征及体外溶出行为研究
Preparation and Characterization of Lurasidone Hydrochloride Solid Dispersion and Study on the in vitro Dissolution Behavior
赵海涛 1宋光西 1殷学治 1吴沉 1王兵1
作者信息
- 1. 常州制药厂有限公司,江苏常州 213018
- 折叠
摘要
Abstract
OBJECTIVE:To prepare the lurasidone hydrochloride solid dispersion,and improve its dissolution rate. METH-ODS:Taking povidone K30 as the carrier,solvent method was used to prepare the lurasidone hydrochloride solid dispersion with different drug-load ratios(1:0.5,1:1,1:2). The in vitro dissolution rates of 3 kinds of lurasidone hydrochloride solid dispersion with physical mixture (lurasidone hydrochloride-povidone K30) and original preparation were compared. X-ray powder diffraction method was adopted to analyze the crystal structures of raw material of lurasidone hydrochloride,povidone K30 and accessories, physical mixture (1:2) and accessories,and lurasidone hydrochloride solid dispersion (1:2) and accessories. RESULTS:Com-pared with physical mixture,the dissolution rate of lurasidone hydrochloride solid dispersion with drug-load ratios of 1:0.5,1:1, 1:2 was significantly improved,and the dissolution rate of solid dispersion was increased as the increase of the carrier ratio. The in vitro dissolution rates of lurasidone hydrochloride solid dispersion with drug-load ratio of 1:2 and original preparation were respec-tively 101.2%and 100.2%in 20 min. X-ray powder diffraction showed,there were characteristic absorption peaks of lurasidone hy-drochloride and accessories in physical mixture;the characteristic absorption peak of lurasidone hydrochloride in solid dispersion disappeared basically,and the characteristic absorption peak of accessories still existed. CONCLUSIONS:The in vitro dissolution of lurasidone hydrochloride solid dispersion with drug-load ratio of 1:2 is similar to original preparation,and lurasidone hydrochlo-ride exists in the solid dispersion as amorphous form.关键词
盐酸鲁拉西酮/固体分散体/聚维酮K30/溶出度Key words
Lurasidone hydrochloride/Solid dispersion/Povidone K30/Dissolution rate分类
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赵海涛,宋光西,殷学治,吴沉,王兵..盐酸鲁拉西酮固体分散体的制备、表征及体外溶出行为研究[J].中国药房,2017,28(34):4876-4878,3.
