中国肿瘤生物治疗杂志2017，Vol.24Issue(11)：1247-1253,7.DOI:10.3872/j.issn.1007-385x.2017.11.001
肿瘤微环境中T细胞功能障碍及其逆转策略
Dysfunction of T cell in tumor microenvironment and strategy of reversing the dysfunction
摘要
Abstract
T cell dysfunction in tumor microenvironment is the key mechanism of tumor escaping from immune surveillance.T cell dysfunction induced by up-regulating expression of immune checkpoint molecules is a hot point of the current research.The clinical trials of blocking immune checkpoint,PD-1 and CTLA-1,have shown encouraging efficacy in the many patients with advanced cancer.It was confirmed that there was T cell dysfunction in tumor microenvironment and reversing T cell dysfunction could play a potentiality in tumor therapy.However,the novel immunotherapy methods exhibited a long-lasting clinical efficacy in a small number of the patients with cancer only,which suggest heterogeneity and complexity of the tumor microenvironment.Recently,the research in unicellular level further clarified phenotypic characteristics and clinical significance of T cell dysfunction in tumor microenvironment,which reveals that epigenetics and metabolic changes are the important mechanisms resulting in T cell dysfunction in the tumor microenvironment and suggests the novel methods for reversing T cell dysfunction in the tumor microenvironment.This paper focus on the latest research progresses of the T cell dysfunction in the tumor microenvironment and strategy of reversing the T cell dysfunction.关键词
肿瘤微环境/T细胞功能障碍/癌症免疫治疗/免疫检查点Key words
tumor microenvironment/T cell dysfunction/immunotherapy for cancer/immune checkpoint分类
医药卫生引用本文复制引用
黄岚,张毅..肿瘤微环境中T细胞功能障碍及其逆转策略[J].中国肿瘤生物治疗杂志,2017,24(11):1247-1253,7.基金项目
国家自然科学基金资助项目(No.31100641,No.31270946)和河南省基础与前沿技术研究项目(No.142300410387).Project supported by the National Natural Science Foundation of China (No.31100641,No.31270946),and the Basic and Advanced Technology Research Program of Henan Province (No.142300410387) （No.31100641,No.31270946）
