中国肿瘤生物治疗杂志2017，Vol.24Issue(11)：1281-1286,6.DOI:10.3872/j.issn.1007-385x.2017.11.007
单份与双份非亲缘脐血移植治疗血液疾病临床效果的比较
Comparation of clinical efficacy of single-unit and double-unit nonrelative cord blood transplantation for therapy of hematonosis
摘要
Abstract
Objective:To comparatively analyze clinical efficacy of single-unit and double-unit nonrelative cord blood transplantation for treatment of hematologic diseases.Methods:Clinical data of the 185 patients received single-unit umbilical cord blood transplantation (SU-UCBT) and the 66 patients received double-unit umbilical cord blood transplantation (DU-UCBT) in 8 domestic transplant centers during 2006 to 2016 were retrospectively analyzed.It was compared that implantation rates,implantation time of neutrophil granulocyte and platelet between SU-UCBT and DU-UCBT,as well as occurrence of acute graft vs host disease (aGVHD) and survival rates of the patients with malignant hematonosis and with non malignant hematonosis after SU-UCBT and DU-UCBT.Results:Implantation rates of the patients received SU-UCBT and DU-UCBT were 78.9％ and 70.7％ respectively,among them implantation rates of the patients with malignant hematonosis were 89.1％ for SU-UCBT and 82.5％ for DU-UCBT as well as implantation rates of the patients with non malignant hematonosis were 64.0％ for SU-UCBT and 53.8％ for DU-UCBT,implantation rates of SU-UCBT and DU-UCBT were similar (P＞0.05).In the patients received SU-UCBT and DU-UCBT,median implantation times of neutrophil granulocyte were all 18 d,median implantation times of platelet were 40 d and 27 d respectively,the difference was not remarkable (P＞0.05).Incidence rates of aGVHD at Ⅰ,Ⅱ,Ⅲ,Ⅳ grades in the patients received SU-UCBT and DU-UCBT were 22.6％,22.6％,8.2％,12.3％ and 21.3％,14.9％,10.6％,10.6％ respectively,all of the differences were not evident (all P＞0.05).Median survival time in the recipients of SU-UCBT and DU-UCBT were 1 460 d (17～2 200 d) and 988 d (21～2 200 d),and their cumulative survival rate of 6 years were respectively 42.5％ and 40.4％,all differences were not obvious (P＞0.05).Conclusion:Between the patients successfully received SU-UCBT and DU-UCBT,implantation times of neutrophil granulocyte and platelet,incidence rate of aGVHD,survival time and cumulative survival rate of 6 years were not significant,which suggests that DU-UCBT could be a safe and effective selection of UCBT.However,the evaluation system of SU-UCBT and DU-UCBT still needs to be perfected and implantation mechanism of DU-UCBT needs to make a thorough inquiry,so as to scientifically guide selection of UCBT.关键词
单份脐血干细胞移植/双份脐血干细胞移植/急性移植物抗宿主病/恶性血液病/回顾性研究Key words
single-unit umbilical cord blood transplantation (SU-UCBT)/double-unit umbilical cord blood transplantation (DU-UCBT)/acute graft vs host disease (aGVHD)/malignant hematonosis/retrospective analysis分类
医药卫生引用本文复制引用
章毅,陈侃俊,李冉,陈亮,卲夏炎,孔静思,陆薇,伍婷..单份与双份非亲缘脐血移植治疗血液疾病临床效果的比较[J].中国肿瘤生物治疗杂志,2017,24(11):1281-1286,6.基金项目
上海市自然科学基金资助项目(No.16ZR1429200) （No.16ZR1429200）
上海市科委研发平台专项资助项目(No.16DZ2293000) （No.16DZ2293000）
2016年上海市专利试点企业项目资助(No.001083816000041) （No.001083816000041）
上海张江国家自主创新示范区专项发展资金重大项目资助(No.ZJ2017-ZD-010).Project supported by the Natural Science Foundation of Shanghai Municipality (No.16ZR1429200),the Special Research and Development Platform Foundation of Shanghai Science and Technology Commission (No.16DZ2293000),the Patent Pilot Enterprise Program 2016 0f Shanghai (No.001083816000041),and the Special Development Foundation for Key Project of Zhangjiang National Independent Innovation Demonstration Area of Shanghai(No.ZJ2017-ZD-010) （No.ZJ2017-ZD-010）
