中国肿瘤生物治疗杂志2017，Vol.24Issue(11)：1304-1308,5.DOI:10.3872/j.issn.1007-385x.2017.11.011
细胞外基质蛋白spondin2在人胃癌组织中的表达及其临床意义
Expression of extracellular matrix protein spondin2 in human gastric carcinoma tissue and its clinical significance
摘要
Abstract
Objective:To explore expression of extracellular matrix protein spondin2 (SPON2) in human gastric carcinoma tissue and its relationship with occurrence of the gastric carcinoma.Methods:Gastric adenocarcinoma and para-carcinoma tissues of 75 patients who hospitalized in Zhangjiagang Hospital affiliated to Suzhou University for eradication of the gastric carcinoma during June 2014 to July 2016 were collected.Immunoflorescence staining was used to survey localization of SPON2 protein in cells of the gastric carcinoma and the para-carcinoma tissues.Expressions of SPON2 in the gastric carcinoma and the para-carcinoma tissues were detected by immunohistochemical staining.Relationship between expression of SPON2 protein and clinicopathological features of the patients with gastric carcinoma was analyzed.Results:SPON2 protein was localized in cytomembrane,cytoplasm and extracellular matrix of the gastric carcinoma cells.Expression of SPON2 protein in the gastric carcinoma tissue was significantly higher than that in the para-carcinoma tissue (72.0％ vs 16.0％,P＜0.01).There was no relationship between expression of SPON2 protein and tumor cell differentiation,gender,age of the patients with gastric carcinoma,as well as there were significant relationships between expression of SPON2 protein and tumor size,TNM staging,invasion degree,lymph node metastasis (all P＜0.05).Conclusion:High expression of SPON2 protein in the gastric carcinoma tissue was related to occurrence and development of the gastric carcinoma,which suggests that SPON2 protein might become a novel marker of early clinical diagnosis and a potential therapeutic target of the gastric carcinoma as well as could forecast prognosis of the patients with gastric carcinoma.关键词
胃癌/脊椎蛋白2/免疫组织化学Key words
gastric carcinoma/spondin2 (SPON2)/immunohistochemistry分类
医药卫生引用本文复制引用
施晓婧,左云,吕燕,顾永娟,王少开..细胞外基质蛋白spondin2在人胃癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(11):1304-1308,5.基金项目
苏州市医学重点诊疗项目资助(No.LCZX201617).Project supported by the Foundation of Suzhou City for Key Medical Diagnosis and Treatment Project (No.LCZX201617) （No.LCZX201617）
