浙江医学2017，Vol.39Issue(19)：1646-1648,后插3,4.DOI:10.12056/j.issn.1006-2785.2017.39.19.2017-629
microRNA-100在急性髓细胞白血病中的预后评估价值研究
Value of miR-100 expression in prognosis of patients with cytogenetically normalacute myeloid leukemia
赵明哲 1胡慧仙 1张素丽 1骆超 1章敬成1
作者信息
- 1. 321000 金华市中心医院(浙江大学金华医院)血液科
- 折叠
摘要
Abstract
Objective To assess the prognostic value of miR-100 expression in patients with cytogenetically normal acute myeloid leukemia (CN-AML).Methods miR-100 expression was detected by real-time quantitative PCR in bone marrow blasts from 154 patients with CN-AML.Patients with miR-100 expression level higher than the median were defined as high expression group.The age,sex,white cells counts (WBC),hemoglobin,platelet counts (PLT) and therapeutic response were compared between high and low expression groups.The overall survival (OS) and event free survival (EFS) were analyzed after 48 months of follow-up.Results Patients with low miR-100 expression had lower hemoglobin and lower percentage of blasts,but higher frequency of FAB M4/5 subtypes.There were no significant differences in age,sex,WBC and PLT,FLT3-ITD and NPM1 gene mutations and complete remission rate between high and low expression groups.Patients with low miR-100 expression had poorer OS and EFS than those with high expression.Conclusion miR-100 expression may be used as a prognostic biomarker for patients with CN-AML.关键词
microRNA-100/急性髓细胞白血病/预后Key words
microRNA-100/Acute myeloid leukemia/Prognosis引用本文复制引用
赵明哲,胡慧仙,张素丽,骆超,章敬成..microRNA-100在急性髓细胞白血病中的预后评估价值研究[J].浙江医学,2017,39(19):1646-1648,后插3,4.
