浙江医学2017，Vol.39Issue(19)：1649-1652,4.DOI:10.12056/j.issn.1006-2785.2017.39.19.2017-1073
18F-FDGPET/CT显像阴性的原发灶不明颈淋巴结转移癌的治疗及预后探讨
Management and prognosis of patients with metastatic cervical lymph nodes from unknown primary site of negative 18F-FDG PET /CT findings
摘要
Abstract
Objective To assess the management and prognosis of patients with metastatic cervical lymph nodes from unknown primary site (CCUP) of negative 18F-FDG PET/CT findings.Methods Twenty four patients with metastatic cervical lymph nodes from unknown primary site (CCUP) of negative 18F-FDG PET/CT findings admitted from July 2013 to June 2016 were retrospectively analyzed.According to the clinic conditions,the neck dissection combined with postoperative radiotherapy and chemotherapy were performed.The clinical efficacy and prognosis of patients were analyzed.Results The overall survival rate was 62.5％(15/24),the median survival time was 24 months,and the 1-,2-and 3-year survival rates were 87.5％ (21/24),70.6％(12/17) and 57.1％(4/7),respectively.There was no significant difference in survival rate between patients with confirmed primary site and those without confirmed primary site before treatment (77.8％ vs.53.3％,P ＞0.05).The survival rate of patients with metastasis to median or upper neck region was higher than that of patients with metastasis to lower or supraclavicular region (81.3％ vs.25.0％,P＜0.05).The survival rate of patients with distant metastasis was lower than that with regional metastasis (33.3％ vs.100.0％,P＜0.05).Conclusion Neck dissection combined with postoperative radiotherapy and chemotherapy is conventionally used for patients with CCUP in whom the primary site is negative in 18F-FDG PET/CT.Early finding the primary site is beneficial for the prognosis,while lower or supraclavicular neck region metastasis or distant metastasis are usually associates with the worse prognosis.关键词
18F-FDG PET/CT/未知原发灶/颈淋巴结转移癌/颈淋巴结清扫/放疗/生存率Key words
18F-FDG PET/CT/Unknown primary site/Metastatic carcinoma of cervical lymph nodes/Neck dissection Radiotherapy/Survival rate引用本文复制引用
黄琦,赵侃,裘世杰,邬振华..18F-FDGPET/CT显像阴性的原发灶不明颈淋巴结转移癌的治疗及预后探讨[J].浙江医学,2017,39(19):1649-1652,4.基金项目
宁波市自然科学基金(2015A610221) （2015A610221）
