浙江医学2017，Vol.39Issue(20)：1745-1747,3.DOI:10.12056/j.issn.1006-2785.2017.39.20.2017-1281
嘉兴地区102例非小细胞肺癌组织标本EGFR基因突变与临床分析
EGFR mutations and clinicopathological features in patients with non-small cell lung cancer
摘要
Abstract
Objective To investigate the correlation of epidermal growth factor receptor (EGFR) gene mutations and clinicopathological characteristics in patients with non-small cell lung cancer (NSCLC).Methods One hundred and two surgical specimens were collected from patients with NSCLC.The EGFR gene mutations were detected by scorpion amplification refractory mutation system (ARMS).Results The mutation rate of EGFR was 50.98％ and that of exon 19/21 was 67.31％.The mutation rates of male and female were 33.33％ and 64.91％,smokers and non-smokers were 37.50％ and 59.68％,medium to high differentiated NSCLC and poorly differentiated NSCLC were 59.02％ and 39.02％,adenocarcinoma and squamous cell carcinoma were 59.04％ and 6.25％(all P＜0.05).The mutation rates of patients aged ＞60 years and ≤60 years were 44.93％ and 63.64％,clinical stages Ⅰ + Ⅱ and clinical stages Ⅲ were 49.32％ and 55.17％,lymphatic metastasis and no lymphatic metastasis were 43.90％ and 55.74％ (all P ＞0.05).Conclusion The EGFR gene mutations are correlated with sex,smoking status,pathological type and differentiation of NSCLC patients.关键词
非小细胞肺癌/表皮生长因子受体/基因突变Key words
Non-small cell lung cancers/Epidermal growth factor/Receptorgenesmutation引用本文复制引用
张军,张凡,周礼湘,徐立栋,高军..嘉兴地区102例非小细胞肺癌组织标本EGFR基因突变与临床分析[J].浙江医学,2017,39(20):1745-1747,3.基金项目
嘉兴市科技局立项课题(2013AY21060) （2013AY21060）
