浙江医学2017，Vol.39Issue(20)：1752-1755,4.DOI:10.12056/j.issn.1006-2785.2017.39.20.2017-873
妊娠早期血清分泌型卷曲相关蛋白5水平对于妊娠糖尿病的早期诊断预测价值
Prediction value of first trimester serum Sfrp-5 level for gestational diabetes mellitus
张伟 1黄素花 1王铁军 1赵绍杰1
作者信息
- 1. 214002 江苏省无锡市妇幼保健院妇产科
- 折叠
摘要
Abstract
Objective To assess the prediction value of first trimester serum secreted frizzle-related protein-5(Sfrp-5) levels for gestational diabetes mellitus (GDM).Methods Three hundred and twenty pregnant women were enrolled in this study and divided to two groups based on glucose tolerance screening:GDM group(n=28) and non-GDM group(n=288).Serum Sfrp-5 levels were measured on first and second trimester of pregnancy.All enrolled pregnant women were receiving insulin resistance(HOMA-IR) and beta cell function evaluation (HOMA-β,INSAUC,PGAUC,INSAUC/PGAUC and △l30/△G30).ROC analysis was used for evaluate the early prediction value of Sfrp-5 for GDM.Pearson correlation was used to analyze the association between GDM and Sfrp-5.Logistic regression was used to determinate the risk factors for GDM.Reaulta The serum Sfrp-5 level,HOMA-β,INSAUC/PGAUC and △I30/△G30 in GDM group were lower than those in non-GDM group on both first and second trimester of pregnancy,while HOMA-IR were higher than those in non-GDM group(all P＜0.05).Correlation analysis showed that contents of Sfrp-5 were negatively associated with GDM on both first and second trimester of pregnancy.ROC analysis suggested that AUC of Sfrp-5 on first trimester of pregnancy was 0.788,the sensitivity and specificity were 82％ and 78％ when 10.5ng/ml was taken as Cut-off value.Logistic analysis indicated that serum Sfrp-5 on first (＜10.5ng/ml) and second trimester (＜6.8ng/ml) of pregnancy were independent risk factors for GDM (OR=1.55 and 1.22,both P＜0.05).Conclusion The reduction of serum Sfrp-5 level on first trimester of pregnancy may be an important warning marker for GDM.关键词
分泌型卷曲相关蛋白5/妊娠糖尿病/早期诊断Key words
Secreted frizzle-related protein-5/Gestational diabetes mellitus/Early diagnosis引用本文复制引用
张伟,黄素花,王铁军,赵绍杰..妊娠早期血清分泌型卷曲相关蛋白5水平对于妊娠糖尿病的早期诊断预测价值[J].浙江医学,2017,39(20):1752-1755,4.
