浙江医学2017，Vol.39Issue(20)：1756-1758,1808,4.DOI:10.12056/j.issn.1006-2785.2017.39.20.2017-43
CCL5在膀胱癌中的表达及临床意义
Expression of CCL5 in patients with bladder cancer and its clinicopathological significance
陈杰 1虞伟星 1马文勇 1范晓松 1何非平 1夏未杰 1李波军1
作者信息
- 1. 312300 绍兴市上虞人民医院泌尿外科
- 折叠
摘要
Abstract
Objective To investigate the expression of CCL5 in tumor tissue of patients with bladder cancer and its clinicopathological significance.Methods The expression of CCL5 protein in 136 specimens of bladder cancer and 20 specimens of normal bladder tissues was detected by SP immunohistochemtry,its correlations with clinicopathologic features of patients was analyzed.Results The expression of CCL5 was higher in tumor tissues than that in normal bladder tissues.The positive rate of CCL5 in low grade bladder cancer was lower than that in high grade bladder cancer (27.3％ vs.55.6％,P=0.01);the expression rate in non-muscle-invasive bladder cancer was lower than that in muscle-invasive bladder cancer (38.3％ vs 57.1％,P=0.041).The patients were followed up for 7-117 months.Kaplan-Meier survival analysis demonstrated that CCL5 expression was significantly associated with shorter overall survival (P＜0.01).Multivariate analysis further demonstrated that CCL5 was an independent prognostic factor for patients with bladder cancer.Conclusion The expression of CCL5 protein is highly in bladder cancer,the detection of the expression of CCL5 protein can be used for diagnosis and prognosis of bladder cancer.关键词
膀胱癌/趋化因子配体5/免疫组化/诊断/预后Key words
Bladder cancer/CCL5/Immunohistochemtry/Diagnosis/Prognosis引用本文复制引用
陈杰,虞伟星,马文勇,范晓松,何非平,夏未杰,李波军..CCL5在膀胱癌中的表达及临床意义[J].浙江医学,2017,39(20):1756-1758,1808,4.
