摘要
Abstract
Objective To investigate the effects of general anesthesia (GA) combined with transversus abdominis plane (TAP) block on intestinal barrier function in the elderly patients undergoing abdominal surgery.Methods Sixty patients undergoing selective abdominal surgery were randomly divided into 2 groups with 30 cases in each group.In group A subcostal ultrasound-guided TAP block was performed after GA in both sides;in group B patients were given GA only.MAP,HR,SpO2,plasma concentrations of D-LAC and I-FABP,bowel function score and VAS score before general anesthesia,at the end of operation,and POD1,POD3,POD5 were recorded.The time to first anal exhaust,defecation,and ambulation,and surgery-related complication were also been recorded.Results There were significant differences in MAP and HR at the end of operation and POD1 compared to those before GA (P＜0.05) in both groups;and the MAP and HR at the end of operation in group A were lower than those in group B (P＜0.05).At the end of operation,POD1 and POD3,plasma D-LAC and I-FABP levels in both groups were significantly higher than those before GA (P＜0.05),and the above indicators in group A were lower than those in group B at the end of operation (P＜0.05).Similarly,bowel function score and VAS score were significantly higher at the end of operation,POD1,POD3 than that before GA (P＜0.05) in both groups;and VAS in group A was lower than that in group B at the end of operation and POD1 (P＜0.05).Besides,the time to first anal exhaust,defecation in group A was earlier than that in group B (P＜0.05),while no significant difference in times to the first ambulation and incidence of complications between group A and group B was observed (P ＞0.05).Conclusion GA combined with TAP block is protective for intestinal barrier function in the elderly patients undergoing abdominal surgery.关键词
全身麻醉/腹横肌平面阻滞/老年患者/腹部手术/肠屏障功能Key words
General anesthesia/Transversus abdominis plane block/The elderly patients Abdominal surgery/Intestinal barrier function
