浙江医学2017，Vol.39Issue(20)：1793-1795,3.DOI:10.12056/j.issn.1006-2785.2017.39.19.2017-411
血清维生素D水平与脑卒中后抑郁的关系
Relationship between serum 25-hydroxyvitamin D level and post-stroke depression
摘要
Abstract
Objective To investigate the correlation between 25 (OH)D level in serum and post-stroke depression (PSD).Methods The serum 25 (OH)D levels were measured in 66 patients with acute cerebral infarction,and depression was assessed in by PHQ-9 at 2-4 weeks after disease onset.According to PHQ-9 scores,the patients were classified into four groups:non-PSD group,mild PSD group,moderate PSD group and severe PSD group.Results The serum 25 (OH)D levels of patients with acute cerebral infarction were significantly lower than those of healthy controls (44.93 ± 17.94nmol/L vs.65.14 ± 19.70nmol/L,t=2.36,P＜0.01).In patients with acute cerebral infarction,serum 25(OH)D levels in PSD group were significantly lower than those in non-PSD group(40.93 ± 14.64nmol/L vs.57.36 ± 16.45nmol/L,t=3.47,P＜0.01),and there were significant differences in serum 25(OH)D levels among mild,moderate and severe PSD groups(41.80 ± 3.07,25.50 ± 3.10,10.80 ± 4.88nmol/L,P＜0.01).Pearson correlation analysis showed that PHQ-9 scores were inversely related to serum 25 (OH)D level (rs=-0.24,P＜0.01).Conclusion Serum 25 (OH)D level is reduced in acute cerebral infarction patients with PSD and it is negatively correlated with the severity of PSD.关键词
维生素D/抑郁/脑卒中Key words
Vitamin D/Depression/Stroke引用本文复制引用
俱西驰,王伟,屈秋民,答嵘,罗国刚,宋文峰..血清维生素D水平与脑卒中后抑郁的关系[J].浙江医学,2017,39(20):1793-1795,3.基金项目
陕西省科学技术研究发展计划基金资助项目(2013K12-01-14),陕西省自然科学基础研究计划基金资助项目(2016JM8006) （2013K12-01-14）
