中南民族大学学报（自然科学版）2017，Vol.36Issue(3)：57-60,4.
蒙药槟榔十三味丸(高尤-13)对慢性应激抑郁模型大鼠肝肾毒性的影响
Effect of Mongolian Betel Shisanwei Ingredients Pill ( Gao-You-13) on Liver and Kidney Toxicity of Chronic Stress Depression Model Rats
摘要
Abstract
In order to observe the effects of Betel Shisanwei ingredients pill (Gao-You-13) on the liver and kidney toxicity of chronic stress depression model rats, 48 male Wistar rats were randomly divided into six groups according to the sugar consumption test (8 rats in each group):low,medium and high dose group (0. 25,0. 5,1. 0 g·kg-1 ) of Gao-You-13 group, fluoxetine group (3.3 mg·kg-1),model group and normal control. Each group was treated with the chronic unpredictable mild stress stimulation under separation except the normal control group. Meanwhile,the rats were given the drugs once daily for 28 days. Then the contents of ALT,AST,UREA and CREA in rats′serum were tested. The liver and kidney tissue morphological changes were observed by HE staining. The results showed that compared with the normal control,ALT levels in model group increased significantly (P<0. 01) and most liver cells appeared mild swelling and degeneration,hepatic sinus narrowed,cell boundaries were unclear(P<0. 05); while ALT levels in Gao-You-13 group decreased significantly compared with the model group (P<0. 01 or P<0. 05). Drug related toxicity lesions did not appear in Gao-You-13 and fluoxetine treatment group (P>0.05). AST,UREA,CREA contents and kidney pathological changes did not show significant differences in each group (P>0. 05). It was confirmed that Gao-You-13 could repair liver damages without liver and kidney toxicity for the chronic stress depression model rats.关键词
槟榔十三味丸/抑郁症/肝肾功能/肝肾病理变化Key words
Betel Shisanwei ingredients pill/depression/hepatorenal function/liver and kidney pathological changes分类
生物科学引用本文复制引用
佟海英,范盎然,李婧,乌吉斯古冷,张月,张少乾,于雪,呼日乐巴根,陈潮光..蒙药槟榔十三味丸(高尤-13)对慢性应激抑郁模型大鼠肝肾毒性的影响[J].中南民族大学学报（自然科学版）,2017,36(3):57-60,4.基金项目
国家自然科学基金资助项目(81202998) （81202998）
