中山大学学报（自然科学版）2017，Vol.56Issue(5)：73-78,6.DOI:10.13471/j.cnki.acta.snus.2017.05.010
南海红树林内生真菌Phomopsis sp.ZZF08酰胺类次级代谢产物
Amide metabolites of the mangrove endophytic fungus Phomopsis sp.ZZF08 from the South China Sea
摘要
Abstract
The amide metabolites of Phomopsis sp.ZZF08 from the South China Sea were isolated and purified by chromatography.Their structures were determined by MS,NMR,X-ray diffraction data and comparison with the li rature data.Cytotoxicity in vitro was performed by tetrazolium (MTT) assay.Twelve amide compounds were isolated,which were viridicatol (1),cytochalasin H (2),cytochalasin Ⅳ (3),glucosylceramide (4),ceramide (5),allantoin (6),thymine (7),pyridine (8),cyclo(Leu-Gly) (9),cyclo-(Leu-Ala) (10),cyclo-(Phe-Gly) (11),and cyclo-(Phe-Ala)(12).Compounds 1,2,3,4 and 5 were isolated firstly from Phomopsis sp.collected from the mangrove bark of the Zhanjiang.In our cytotoxicity assays,compounds 2 and 3 exhibited strong cytotoxicity toward KB cells and KBv200 cells.关键词
红树林/内生真菌/拟茎点霉菌/酰胺类次级代谢产物Key words
mangrove/endophytic fungus/Phomopsis sp./amide metabolites分类
化学引用本文复制引用
陶移文,凌惠平,张建业,佘志刚,林永成..南海红树林内生真菌Phomopsis sp.ZZF08酰胺类次级代谢产物[J].中山大学学报（自然科学版）,2017,56(5):73-78,6.基金项目
广东省自然科学基金(2016A030313588) （2016A030313588）
广东省科技计划项目(2013B021100021) （2013B021100021）
广州市教育局项目(1201610155) （1201610155）
