川北医学院学报2017，Vol.32Issue(5)：670-672,3.DOI:10.3969/j.issn.1005-3697.2017.05.006
人乳头瘤病毒E6/E7蛋白在宫颈病变筛查中的应用
Application of human papilloma virus E6/E7 protein in screening cervical lesions
魏彩平1
作者信息
- 1. 广西科技大学附属柳州市人民医院妇科,广西柳州545006
- 折叠
摘要
Abstract
Objective:To explore the effect of human papilloma virus (HPV) E6/E7 protein in screening cervical lesions.Methods:A total of 70 patients with cervical lesions were selected and given cervical pathological examinations and ThinPrep liquidbased cytology (TCT) detection.The sensitivity and specificity of high-risk HPV E6/E7 mRNA detection and HPV DNA subtype detection were compared in detecting cervical cancer lesions and the high-degree cervical cancer lesions in patients with atypical squamous cells (ASC-US).Results:The total detection rates of high-risk H PV E6/E7 mRNA detection and HPV DNA subtype detection in detecting cervical lesions were 60.0％ (42/70) and 67.1％ (47/70),respectively.There was no significant difference between two methods in the detection rates of chronic cervicitis,cervical intraepithelial neoplasm (CIN) Ⅰ,CIN Ⅱ ～ Ⅲ and cervical cancer (P ＞ 0.05).There was no significant difference in sensitivity,positive predictive value and negative predictive value between two methods in detecting cervical lesions (P ＞ 0.05),but high-risk HPV E6/E7 mRNA detection was notably higher than HPV DNA subtype detection in the specificity (P ＜ 0.05).In patients with ASC-US,high-risk HPV E6/E7 mRNA detection was notably higher than HPV DNA subtype detection in the specificity (P ＜ 0.05).Conclusion:Compared with HPV DNA subtype detection,high-risk HPV E6/E7 mRNA detection is stronger in specificity in predicting cervical lesions,which is especially more definite in the distribution management of patients diagnosed as ASC-US by TCT.关键词
人乳头瘤病毒/宫颈病变/非典型鳞状细胞/新柏氏液基细胞学Key words
Human papilloma virus/Cervical lesion/Atypical squamous cell/ThinPrep liquid-based cytology分类
医药卫生引用本文复制引用
魏彩平..人乳头瘤病毒E6/E7蛋白在宫颈病变筛查中的应用[J].川北医学院学报,2017,32(5):670-672,3.
