川北医学院学报2017，Vol.32Issue(5)：725-727,3.DOI:10.3969/j.issn.1005-3697.2017.05.022
吸烟对HDL-C正常者的胆固醇外流功能影响的研究
Study the effects of smoking on cholesterol efflux function in healthy subjects with normal HDL-C
摘要
Abstract
Objective:To investigate and compare the HDL related cholesterol efflux capabilities between smokers and non-smokers without arteriosclerotic cardiovascular disease,and to determine the effects of smoking on reverse cholesterol transport.Methods:42 smoking patients with normal HDL in smoking group and 42 non-smoking patients in control group were included.The effect of HDL in peripheral blood plasma on the efflux rate of J774A.1 macrophages was measured by cholesterol efflux fluorescence analysis.Results:The capability of HDL to activate cholesterol efflux was shown to reduce significantly in smoking group,compared with non-smoking group(25.72 ±7.36％ vs.29.53 ±7.97％).the two groups of subjects in the general situation,blood lipid spectrum and high sensitivity C reactive protein basically the same situation,the difference was statistically significant (P ＜ 0.05).Conclusion:HDL related cholesterol efflux rate in smokers was significantly lower than that of non-smokers,smokers showed that HDL anti atherosclerosis function is obviously weakened,suggesting the importance of smoking cessation in the primary prevention of cardiovascular diseases.关键词
吸烟/高密度脂蛋白,胆固醇外流率Key words
Smoking/High-density lipoprotein/Cholesterol efflux分类
医药卫生引用本文复制引用
邓晓剑,顾建华,何顶秀,黄楷森..吸烟对HDL-C正常者的胆固醇外流功能影响的研究[J].川北医学院学报,2017,32(5):725-727,3.基金项目
四川省医学会青年创新课题(Q16027、Q15064) （Q16027、Q15064）
