川北医学院学报2017，Vol.32Issue(5)：768-770,3.DOI:10.3969/j.issn.1005-3697.2017.05.034
短期胰岛素泵强化治疗对初诊2型糖尿病患者糖脂代谢及胰岛β细胞功能的影响
Effect of short-term continuous subcutaneous insulin infusion treatment on the glucolipid metabolism and islet beta-cell function of first-visit patients with T2DM
王晓光 1张薇 1任珍 2焦凯1
作者信息
- 1. 第四军医大学唐都医院内分泌科,陕西西安710038
- 2. 长安大学医院内科,陕西西安710018
- 折叠
摘要
Abstract
Objective:To explore the effect of short-term continuous subcutaneous insulin infusion treatment on the glucolipid netabolism and islet beta-cell function of first-visit patients with type 2 diabetes mellitus (T2DM).Methods:Totally 74 first-visit T2DM patients were randomly assigned into control group (n =37) and research group (n =37).The patients in control group were given routine treatment,while those in research group given short-term continuous subcutaneous insulin infusion treatment.The changes of blood glucose,blood lipids and islet beta-cell function were all observed in two groups before and after treatment.Results:After treatment,the levels of fasting blood glucose (FPG),glycosylated hemoglobin (HbAlc),total cholesterol (TC),triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) all went down,while that of high density lipoprotein cholesterol (HDL-C) up in two groups when compared with pre-treatment,and the improvement degree of research group was more significant (P ＜ 0.05).After treatment,the area under the curve (AUC) of insulin,homeostasis model assessment-islet beta-cell function (HOMA-β) and the ratio of I30/G30 increased,whereas homeostasis model assessment insulin resistance (HOMA-IR) decreased significantly in two groups when compared with pre-treatment,and the improvement degree of research group was more significant (P ＜0.05).Conclusion:For first-visit T2DM patients,short-term continuous subcutaneous insulin infusion treatment can impove the glucolipid metabolism,and is conductive to repair of injured islet beta cells.关键词
2型糖尿病/胰岛素泵/胰岛β细胞/糖脂代谢Key words
Type 2 diabetes mellitus/Insulin pump/Islet beta cells/Glucolipid metabolism分类
医药卫生引用本文复制引用
王晓光,张薇,任珍,焦凯..短期胰岛素泵强化治疗对初诊2型糖尿病患者糖脂代谢及胰岛β细胞功能的影响[J].川北医学院学报,2017,32(5):768-770,3.
