重庆医学2017，Vol.46Issue(36)：5052-5054,3.DOI:10.3969/j.issn.1671-8348.2017.36.005
SD大鼠极端高温高湿环境暴露的实验研究
The experimental research of the SD rats exposed to the high-temperature and high-humidity environment
摘要
Abstract
Objective To investigate the effect of extremely high temperature and high humidity exposure on the survival and blood biochemical indexes of SD rats and the to the major organs .Methods Twenty-six SD rats were divided into the normal tem-perature and humidity group and the extremely high-temperature and high-humidity group .The mortality of SD rats in extremely high-temperature and high humidity environment was observed ,and at the median lethal time ,the living rats were undergoing the tests of serum biochemical indicators and the pathological examination of the heart ,lung ,kidney ,brain ,muscles and intestinal tis-sues .Results The exposure to the extremely high-temperature and high-humidity environment could lead to the death of SD rats , the median lethal time was 48 h .The serum creatinine(Scr) increased significantly(P<0 .05) ,and the serum alkaline phosphatase (ALP) and ischemia modified albumin (IMA) decreased significantly (P<0 .05) when compared with the normal temperature and humidity group ,and there was no significant difference in other biochemical indicators .The inflammatory cell infiltration was ob-served in heart ,lung ,kidney and intestines ,and there were no obvious pathological changes in brain and muscle .Conclusion The exposure to the extremely high-temperature and high-humidity environment has obvious lesion on SD rats ,it can lead to the abnor-mality of some biochemical indicators ,the inflammatory changes in heart ,lung ,kidney and intestines ,and even death .关键词
高温/高湿/环境暴露/大鼠,Sprague-Dawley/生物学标记/病理学,临床Key words
high-temperature/high-humidity/environmental exposure/rats/Sprague-Dawley/biological markers/pathology/clinical分类
生物科学引用本文复制引用
刘刚,刘诗颖,黄伍蓉,简燚,呼永河,吴丽娟..SD大鼠极端高温高湿环境暴露的实验研究[J].重庆医学,2017,46(36):5052-5054,3.基金项目
四川省科技厅青年科技创新研究团队资助(2013TD0016 ). （2013TD0016 ）
