重庆医学2017，Vol.46Issue(36)：5071-5073,3.DOI:10.3969/j.issn.1671-8348.2017.36.011
远隔缺血后适应对急性心肌梗死再灌注治疗患者血小板功能的影响
Effect of remote ischemic postconditioning on platelet function in patients with myocardial ischemia-reperfusion
摘要
Abstract
Objective To investigate the effect of remote ischemic postconditioning (RIPostC ) on the platelet reactivity in the patients with acute myocardial infarction (AMI) receiving reperfusion therapy .Methods Seventy-one cases of AMI entering the group received the reperfusion therapy .The patients were divided into the two groups .The treatment group received RIPostC ,while the control group received sham RIPostC .The venous blood samples were collected before transcutaneous coronary intervention (PCI) ,instantly after RIPostC and at 24 h ,48 h after PCI .The platelet activation indicators CD62P and PAC-1 ,and platelet apopto-sis indicator mitochondrial transmembrane potential(ΔΨm) were measured by flow cytometry .Results CD62P expression on plate-let surface at 24 h after PCI in the treatment group was significantly lower than that in the control group (P<0 .05) ,but which at other time points had no statistical difference between the two groups (P>0 .05);there was no statistical difference in platelet PAC-1 expression at each time point between the two groups (P>0 .05);the platelet ΔΨm at each time point had no statistical difference between the two groups(P>0 .05) .Conclusion RIPostC can somewhat reduce platelet activation in AMI patients without causing platelet early apoptosis .关键词
心肌梗死/血小板活化/缺血后适应Key words
myocardial infarction/platelet activation/ischemic postconditioning分类
医药卫生引用本文复制引用
钱云霞,何志松,杨向军..远隔缺血后适应对急性心肌梗死再灌注治疗患者血小板功能的影响[J].重庆医学,2017,46(36):5071-5073,3.基金项目
国家自然科学基金资助项目(81400200 ). （81400200 ）
