南方医科大学学报2017，Vol.37Issue(12)：1678-1682,5.DOI:10.3969/j.issn.1673-4254.2017.12.20
影响大动脉粥样硬化性脑梗死复发的危险因素
Risk factors for recurrence of large atherosclerotic cerebral infarction
摘要
Abstract
Objective To explore the risk factors for recurrence of large atherosclerotic cerebral infarction in first-episode patients. Methods The consecutive patients with acute cerebral infarction diagnosed in the Department of Neurology were screened for large atherosclerotic cerebral infarction by CTA/MRA examination,and all the confirmed patients were followed up for 1 year.The patients were divided into recurrent ischemic stroke group and non-recurrent group according to occurrence of cerebrovascular events during the follow-up.Results A total of 256 eligible patients were included in this study,and all of them completed the follow-up. During the 1-year follow-up, 30 (11.7%) patients had ischemic cerebrovascular stroke events. Univariate analysis showed significant differences in alcohol drinking (P=0.028), smoking (P=0.007), high-density lipoprotein cholesterol (HDL; P=0.045), ischemic heart disease (P=0.002), antihypertensive agents (P=0.036) and statin use (P=0.016) between the recurrent group and non-recurrent group.Cox regression analysis showed that irregular use of statins(RR=0.410, P=0.043), smoking (RR=2.253, P=0.043), HDL (RR=0.327, P=0.029), and ischemic heart disease (RR=8.566, P<0.001) were correlated with recurrent ischemic stroke.Conclusion The first-episode patients with irregular use of statins,low HDL levels, smoking and ischemic heart disease are at higher risks for having ischemic stroke recurrence.关键词
脑梗死/卒中复发/危险因素Key words
cerebral infarction/recurrent stroke/risk factor引用本文复制引用
戴颖仪,黄志新,刘新通,王启章..影响大动脉粥样硬化性脑梗死复发的危险因素[J].南方医科大学学报,2017,37(12):1678-1682,5.基金项目
广州市科技计划项目(201707010436) （201707010436）
广东省中医药局科研项目(20173024) （20173024）
广东省第二人民医院引进人才科研启动基金(YY2016-005) （YY2016-005）
深圳市科技计划项目(JCYJ20150402095058880) （JCYJ20150402095058880）
