南方医科大学学报2017，Vol.37Issue(12)：1683-1687,5.DOI:10.3969/j.issn.1673-4254.2017.12.21
早发性卵巢功能不全患者赠卵IVF获得妊娠在孕期合并系统性红斑狼疮:1例报告并文献复习
Pregnancy outcome in a woman with premature ovarian insufficiency complicated by systemic lupus erythematosus during pregnancy:a case report
摘要
Abstract
We report a case of in vitro fertilization and embryo transfer (IVF-ET) with oocyte donation in a woman with premature ovarian insufficiency(POI)complicated by systemic lupus erythematosus(SLE)during pregnancy.The patient had a diagnosis of POI 4 years earlier and 11 weeks after successful pregnancy by IVF-ET with oocyte donation in 2003, she presented with facial edema,and further examinations confirmed the diagnosis of lupus nephritis.She received treatment with prednisone to control the activity of SLE and aspirin and low-molecular-weight heparin to improve placental blood flow with close monitoring of gravida and fetus throughout pregnancy. The condition of the patient remained unstable during pregnancy,and liver damage and placental circulation disorder occurred in late gestational weeks with suspected intrauterine growth retardation (IUGR) of the fetus. For maternal and fetal safety, the patient received elective caesarean section and delivered a premature boy at 31 weeks of gestation.She subsequently received further medications for SLE and showed good recovery of the immunological parameters and absence of SLE symptoms during the follow-up for 14 years, indicating a clinical cure of SLE. Her son shows normal growth and development. Based on the experience with this case and literature review, we believe that immunological factor is an important cause of POI and thus recommend full immunological examinations in cases of idiopathic POI.关键词
早发性卵巢功能不全/赠卵妊娠/系统性红斑狼疮Key words
premature ovarian insufficiency/pregnancy/systemic lupus erythematosus引用本文复制引用
陈婉乐,陈士岭,刘玉东,李雪兰,冯淑娴,周星宇,马伟旭,黎莹,叶德盛,陈薪..早发性卵巢功能不全患者赠卵IVF获得妊娠在孕期合并系统性红斑狼疮:1例报告并文献复习[J].南方医科大学学报,2017,37(12):1683-1687,5.基金项目
南方医科大学临床研究重点项目(LC2016ZD010) （LC2016ZD010）
国家重点研发计划"生殖健康及重大出生缺陷防控研究"重点专项项目(2017YFC1001100) （2017YFC1001100）
