基于稀土上转换纳米荧光探针的肿瘤标志物体外检测
Lanthanide-doped Upconversion Nano-bioprobes for In-vitro Detection of Tumor Markers
摘要
Abstract
Sensitive and specific biodetection of tumor markers is essential for early-stage cancer diagnosis and ther-apy,and will ultimately increase the patient survival rate.As a new generation of luminescent nano-bioprobes,triva-lent lanthanide(Ln3+)-doped upconversion(UC)nanoparticles(NPs)possess exceptional properties such as near-infrared triggered anti-Stokes luminescence and long excited-state lifetime,and thus are considered to be the most promising alternative to conventional probes such as organic dyes,lanthanide chelates and quantum dots for early cancer theranostics.In this review,we provide a brief overview of the most recent advances in the development of Ln3+-doped UC nano-bioprobes,which covers from their chemical and physical fundamentals to biodetection including the controlled synthesis,surface modification,optical spectroscopy and their in-vitro UC luminescent bioassay of tumor markers.Some future prospects and challenges in this rapidly growing field are finally envisioned.关键词
稀土/上转换发光/肿瘤标志物/纳米晶/生物检测Key words
lanthanide ion/upconversion/tumor maker/nanoparticle/bioassay分类
数理科学引用本文复制引用
于莉华,刘永升,陈学元..基于稀土上转换纳米荧光探针的肿瘤标志物体外检测[J].发光学报,2018,39(1):27-49,23.基金项目
中国科学院战略重点研究计划(XDB20000000,XDA09030102) （XDB20000000,XDA09030102）
973国家重大科学研究计划(2014CB845605) （2014CB845605）
国家自然科学基金(21771185,21473205,U1305244,21325104) （21771185,21473205,U1305244,21325104）
中国科学院/国家外专局创新研究团队国际合作项目 （）
中国科学院青年创新促进会项目 （）
福建省自然科学基金(2017I0018,2017J01038)资助项目Supported by The Strategic Priority Research Program of The CAS(XDB20000000,XDA09030102) （2017I0018,2017J01038）
973 National Major Scientif-ic Research Program(2014CB845605) （2014CB845605）
National Natural Science Foundation of China(21771185,21473205,U1305244,21325104) （21771185,21473205,U1305244,21325104）
CAS/SAFEA International Partnership Program for Creative Research Teams （）
Youth Innovation Promotion Associa-tion of CAS （）
Natural Science Foundation of Fujian Province (2017I0018,2017J01038) （2017I0018,2017J01038）
