高等学校化学学报2018，Vol.39Issue(1)：32-40,9.DOI:10.7503/cjcu20170539
利用DNA三维纳米结构对量子点功能化的有序调控
Programming Single Quantum Dot Valencies via DNA Caging
摘要
Abstract
A fundamental unsolved problem for quantum dot( QD) chemistry is to simultaneously control the type, number and spatial orientation of QD valencies ( i. e., the binding sites on each QD). Herein, we demonstrate a strategy to generate structurally predicable multivalent QD with uniform valency type, number and spatial orientation by caging the QD in a DNA cube by DNA nanotechnology. The results show that diffe-rent DNA valencies could be anchored to specific positions of the cube to form homogeneous DNA-functiona-lized QD with adjacent or diagonal valencies. As a proof-of-concept study, different sizes of gold nanoparticles ( GNPs) were conjugated to each QD valency through DNA hybridization. The resulting bivalent and trivalent QD conjugates not only possess the same GNP number but also uniform assembly geometry by low magnifica-tion and high-resolution TEM. This approach holds great potential for generating multivalent and multifunc-tional QD probes for advanced biological applications.关键词
DNA/量子点/功能化/金纳米粒子Key words
DNA/Quantum dot/Functionalization/Gold nanoparticles分类
化学化工引用本文复制引用
王莉,李智,沈晓琴,马楠..利用DNA三维纳米结构对量子点功能化的有序调控[J].高等学校化学学报,2018,39(1):32-40,9.基金项目
国家自然科学基金(批准号:21175147,91313302,21475093)、 国家"八六三" 计划项目(批准号:2014AA020518)和青年海外高层次人才引进计划资助.基金项目: 国家自然科学基金(批准号:21175147,91313302,21475093)、 国家"八六三" 计划项目(批准号:2014AA020518)和青年海外高层次人才引进计划资助. Supported by the National Natural Science Foundation of China(Nos.21175147,91313302,21473093),the National High Technology Research and Development Program of China( No.2014AA020518) and the Young Overseas High-level Talents Introduction Plan of China. （批准号:21175147,91313302,21475093）
