国际妇产科学杂志2017，Vol.44Issue(6)：610-613,625,5.
滋养细胞焦亡与子痫前期发病机制的研究进展
The Pyroptosis of Trophoblast in Relation to Preeclampsia
摘要
Abstract
Preeclampsia (PE) is the normal complication during pregnancy, Which seriously influences the maternal-fetal outcomes. The mechanisms are not clear. Vascular endothelial injury and over-reaction of inflammation are believed to be the main pathogenesis. It has been found that there is a close relationship between trophoblast pyroptosis and PE. On the one hand, pyroptosis reduces the invasion of trophoblast, which infiltrating too shallow or restricted, leading to abnormal blood vessels recasting, maternal-fetal interface ischemia and hypoxia. On the other hand, the release of inflammatory factors induces immune cells gathered, activates excessive inflammatory reactions, damages endothelial cell, leading to the occurrence of PE. In this paper, The relationships of trophoblast pyroptosis and the pathogenesis of PE are summarized as follows.关键词
先兆子痫/滋养层/细胞死亡/炎症/焦亡Key words
Preeclampsia/Trophoblast/Cell death/Inflammation/Pyroptosis引用本文复制引用
孙白云,乔东艳,于红..滋养细胞焦亡与子痫前期发病机制的研究进展[J].国际妇产科学杂志,2017,44(6):610-613,625,5.基金项目
江苏省科技计划项目(BK20161432) （BK20161432）
