国际口腔医学杂志2018，Vol.45Issue(1)：46-49,4.DOI:10.7518/gjkq.2018.01.009
微小RNA在人牙周膜来源细胞成骨分化中的作用
Functions of microRNA on the osteogenic differentiation of human periodontal ligament-derived cells
摘要
Abstract
Human periodontal ligament-derived cells are a group of heterogeneous cells, which can differentiate into osteoblasts, participate in remodeling and repair of alveolar bone remodeling, and periodontal regeneration. MicroRNAs (miRNAs) are thought to play a key role in the regulation of cell differentiation and be key factors in maintaining cell differentiation and regulating differentiation. MicroRNA plays a promotion or inhibition role on osteogenic differentiation by targeting mRNA. In this review, we summarized the different miRNAs in the osteogenic differentiation of periodontal-derived cells, focusing on the function and regulation of target genes and pathways under the mineralized or mechanical force induced conditions.关键词
微小RNA/牙周膜干细胞/牙周膜细胞/成骨分化Key words
microRNA/periodontal ligament stem cell/periodontal ligament cell/osteogenic differentiation分类
生物科学引用本文复制引用
郝奕霖,房付春,吴补领..微小RNA在人牙周膜来源细胞成骨分化中的作用[J].国际口腔医学杂志,2018,45(1):46-49,4.基金项目
国家自然科学基金(81600882) （81600882）
广东省医学科学技术研究基金(A2016190)This work was supported by National Natural Science Foundation of China (81600882) and Medical Science and Technology Research Fundation of Guangdong Province (A2016190). （A2016190）
