海南医学院学报2017，Vol.23Issue(20)：2757-2760,4.DOI:10.13210/j.cnki.jhmu.20171010.001
替米沙坦联合硝苯地平控释片治疗对冠心病伴轻中度高血压患者炎性因子、血管内皮功能及左心室功能的影响
Effects of telmisartan combined with nifedipine controlled release tablet on inflammatory fac-tors,vascular endothelial function and left ventricular function in patients with coronary heart disease with mild to moderate hypertension
摘要
Abstract
Objective:To investigate the effect of telmisartan combined with Nifedipine Controlled Release Tablet on in-flammatory factors,vascular endothelial function and left ventricular function in patients with coronary heart disease with mild to moderate hypertension.Methods:A total of 92 cases of patients with coronary heart disease with mild to moderate hyperten-sion were selected as the object of observation,according to the random data table,they were divided into the control group(n=46)and observation group(n=46),and patients in the control group were treated with Nifedipine Controlled Release Table therapy,on this basis,the observation group patients were given telmisartan treatment,two groups were treated for 6 months. The levels of the blood pressure,inflammatory factors,vascular endothelial function and left ventricular function were com-pared between the two groups before and after treatment.Results:There were no significant differences in the levels of SBP, DBP,hs-CRP,TNF-α,NO,ET-1,LVEF,LVEDD and LVESD in the two groups before treatment(P>0.05);After treat-ment,two groups of SBP,DBP,hs-CRP,TNF-α,ET-1,LVEDD and LVESD levels were significantly lower than those in the same group before treatment(P<0.05),and after treatment,the levels of SBP,DBP,hs-CRP,TNF-α,ET-1 and LVESD in the observation group were significantly lower than those in the control group(P< 0.05),while there were no significant difference in the level of LVEDD between the two groups after treatment(P>0.05);Compared with level in the group before treatment,the levels of NO and LVEF in the two groups were significantly increased(P<0.05),and the observation group [(82.13 ± 19.01)μmol/L,(52.83 ± 7.45)%]was significantly higher than the control group[(67.37 ± 13.08)μmol/L,(49.47 ± 6.96)%](P<0.05).Conclusion:Telmisartan combined with Nifedipine Controlled Release Table in treating coronary heart disease with mild to moderate hypertension,can effectively control blood pressure,reduce the inflammatory stress,improve vascular endothelial function and left ventricular function of patients,has an important clinical value.关键词
冠心病伴轻中度高血压/替米沙坦/硝苯地平控释片/炎性因子/血管内皮功能/左心室功能Key words
Coronary heart disease with mild to moderate hypertension/telmisartan/Nifedipine Controlled Release Table/inflammatory factors/vascular endothelial function/left ventricular function分类
医药卫生引用本文复制引用
郭峰,张宝娓,朱正炎..替米沙坦联合硝苯地平控释片治疗对冠心病伴轻中度高血压患者炎性因子、血管内皮功能及左心室功能的影响[J].海南医学院学报,2017,23(20):2757-2760,4.基金项目
北京市卫生局资助基金(201712344)It is supported by Beijing Municipal Health Bureau Fund(201712344). （201712344）
