海南医学院学报2017，Vol.23Issue(20)：2776-2778,2782,4.DOI:10.13210/j.cnki.jhmu.20171009.002
厄贝沙坦联合阿托伐他汀治疗对早期糖尿病肾病患者血清Cys C、Hcy、TNF-α、ET、TGF-b1水平的影响
Effects of Irbesartan combined Atorvastatin on serum levels of Cys C,Hcy,TNF-α,ET, TGF-b1 in patients with early diabetic nephropathy
摘要
Abstract
Objective:To observe the effects of Irbesartan combined with Atorvastatin on early diabetic nephropathy pa-tients' serum Cys C,Hcy,TNF-α,ET and TGF-b1 levels.Methods:A total of 60 early diabetic nephropathy patients were randomly divided into observation group(30cases)and control group(30 cases).Observation group:Irbesartan combined with Atorvastatin;control group:patients were treated only by Irbesartan.Recording and comparing the levels of Cys C,Hcy, TNF-α,ET and TGF-b1 before and after treatment.Results:(1)Before treatment,there was no statistically significant differ-ence in the serum FBG,TG,Scr,BUN levels between the two groups(P>0.05).After treatment,compared with the same group before treatment,the serum TG,Scr,BUN levels of the two groups were significantly lower(P<0.05),and those lev-els of observation group were significantly better than the control group,the difference between two groups was statistically significant(P<0.05);(2)Before treatment,there was no statistically significant difference in the serum Cys C,Hcy,TNF-α, ET,TGF-b1 levels between the two groups(P>0.05).After treatment,compared with the same group before treatment,the serum Cys C,Hcy,TNF-α,ET,TGF-b1 levels of the two groups were significantly lower(P<0.05),and those levels of ob-servation group were significantly better than the control group,the difference between two groups was statistically significant (P<0.05).Conclusion:Irbesartan combined with Atorvastatin for early diabetic nephropathy patients can reduce the levels of serum Cys C,Hcy,TNF-α,ET,TGF-b1 and be beneficial to protect their nephritic function.关键词
早期糖尿病肾病/厄贝沙坦/阿托伐他汀/CysC/Hcy/TNF-α/ET/TGF-b1Key words
Early diabetic nephropathy/Irbesartan/Atorvastatin/Cys C/Hcy/TNF-α/ET/TGF-b1分类
医药卫生引用本文复制引用
热孜万古丽·阿布都拉,宋雪..厄贝沙坦联合阿托伐他汀治疗对早期糖尿病肾病患者血清Cys C、Hcy、TNF-α、ET、TGF-b1水平的影响[J].海南医学院学报,2017,23(20):2776-2778,2782,4.基金项目
新疆维吾尔自治区自然科学基金(2015172B022)This study was supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2015172B022)． （2015172B022）
