海南医学院学报2017，Vol.23Issue(20)：2794-2797,4.DOI:10.13210/j.cnki.jhmu.20171012.001
右美托咪定对腹腔镜子宫全切患者炎症反应及氧化应激水平的影响
Effects of dexmedetomidine on inflammatory response and oxidative stress in laparoscopic hysterectomy patients
摘要
Abstract
Objective:To investigate the effect of dexmedetomidine on inflammatory response and oxidative stress in pa-tients with laparoscopic total hysterectomy.Methods:Ninety patients with laparoscopic hysterectomy under general anesthesia were selected in our hospital from January 2015 to December 2016,and randomly divided into control group and observation group,Each group of 45 cases.The observation group was given dexmedetomidine,intravenous pump injection,The control group was given the same amount of saline in the same manner,followed by anesthesia induction.The hemodynamics,inflam-matory factors and oxidative stress were monitored before anesthesia(T0),30 minutes after the end of pneumoperitoneum(T1),after operation(T2)and at the end of 24 hours(T3).Results:Compared with T0,T1,T2 and T3,the observation group of patients with MAP and HR levels were no significant difference;T3,the control group MAP and HR levels were not significantly different;T1 and T2,MAP and HR levels in the control group were significantly increased(P<0.05),And sig-nificantly higher than the observation group(P<0.05);Compared with T0,the levels of CRP,TNF-α and IL-1β in patients were significantly increased in T1,T2 and T3,but the levels of CRP,TNF-α and IL-1β in the observation group were signifi-cantly lower than those in the control group(P<0.05);Compared with T0,both groups of patients with H2O2and MDA lev-els were significantly increased,TAS levels were significantly reduced,the difference was statistically significant(P<0.05), However,the levels of H2O2and MDA in the observation group were significantly lower than those in the control group,the level of TAS was significantly higher than the control group(P<0.05).Conclusion:Laparoscopic hysterectomy increases the inflammatory response and oxidative stress in patients,while the use of dexmedetomidine can maintain hemodynamic stability in a certain extent,reduce the inflammatory response and reduce oxidative stress Injury,it is worth of further clinical applica-tion.关键词
右美托咪定/腹腔镜子宫全切患者/炎症反应/氧化应激Key words
Dexmedetomidine/laparoscopic hysterectomy/inflammatory response/oxidative stress引用本文复制引用
范哲,卢江明,周晓娟,张平,龚辉..右美托咪定对腹腔镜子宫全切患者炎症反应及氧化应激水平的影响[J].海南医学院学报,2017,23(20):2794-2797,4.基金项目
陕西省科学技术发展项目(SX-34-12-L)Shaanxi science and technology development project(SX-34-12-L) （SX-34-12-L）
