海南医学院学报2017，Vol.23Issue(20)：2804-2807,4.DOI:10.13210/j.cnki.jhmu.20170928.002
子痫前期患者母体-胎盘循环超声参数与胎盘缺氧及氧化应激程度的相关性
Correlation of maternal-placental circulation ultrasound parameters with placental hypoxia and oxidative stress in patients with preeclampsia
摘要
Abstract
Objective:To study the correlation of maternal -placental circulation ultrasound parameters with placental hypoxia and oxidative stress in patients with preeclampsia.Methods:Patients with preeclampsia who gave birth in Shandong jiaotong hospital between March 2015 and February 2017 were select as the PE group of the study,and the healthy pregnant women who gave birth in hospital during the same period were selected as the control group of the study.Color Doppler ultra-sonography was done in the 23-26 weeks of pregnancy to determine the uterine spiral artery PI,RI and S/D levels;after deliv-ery,the placenta was collected to determine the expression of hypoxia-induced apoptosis indexes,cell invasion molecules and oxidative stress molecules.Results:Uterine spiral artery PI,RI and S/D levels of PE group were significantly higher than those of control group;TXNIP,NLRP3,ASC,Caspase-1,Nrf-2,HO-1 and NQO-1 mRNA expression in placenta tissue of PE group were significantly higher than those of control group and positively correlated with uterine spiral artery PI,RI and S/D levels while CatL,CatB,uPA and LAMA4 mRNA expression were significantly lower than those of control group and nega-tively correlated with uterine spiral artery PI,RI and S/D levels.Conclusion:The increase of maternal- placental circulation blood resistance in patients with preeclampsia will result in the placental hypoxia,and aggravate the apoptosis and oxidative stress.关键词
子痫前期/母体-胎盘循环/凋亡/侵袭/氧化应激Key words
Preeclampsia/maternal-placental circulation/apoptosis/invasion/oxidative stress分类
医药卫生引用本文复制引用
赵敏..子痫前期患者母体-胎盘循环超声参数与胎盘缺氧及氧化应激程度的相关性[J].海南医学院学报,2017,23(20):2804-2807,4.基金项目
国家自然科学基金青年项目(81402153)It is supported by National Natural Science Foundation Project for Youth Talents(81402153)． （81402153）
