海南医学院学报2017，Vol.23Issue(20)：2862-2865,2869,5.DOI:10.13210/j.cnki.jhmu.20170926.009
早期肠内营养干预对高血压脑出血患者神经功能、全身氧化应激及炎症反应的影响
Effect of early enteral nutrition intervention on nerve function,systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage
摘要
Abstract
Objective:To study the effect of early enteral nutrition intervention on nerve function,systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.Methods:A total of 98 patients with hy-pertensive cerebral hemorrhage who received hospitalization in the hospital between April 2015 and February 2017 were collect-ed and divided into control group and observation group by random number table method,49 cases in each group.Control group received routine enteral nutrition intervention and observation group received early enteral nutrition intervention.The differences in serum levels of nerve function-related indexes,oxidative stress indexes and inflammatory mediators were com-pared between the two groups of patients before and after intervention.Results:Before intervention,the differences in serum levels of nerve function-related indexes,oxidative stress indexes and inflammatory mediators were not statistically significant between the two groups of patients.After 1 week of intervention,serum S100B,NSE,GFAP,MBP,LPO,MDA,PCT,IL-1β,IL-6 and TNF-α levels of both groups of patients were lower than those before intervention while GSH-PX levels were higher than those before intervention,and serum S100B,NSE,GFAP,MBP,LPO,MDA,PCT,IL-1β,IL-6 and TNF-α lev-els of observation group were lower than those of control group while GSH-PX level was higher than that of control group. Conclusion:Early enteral nutrition intervention can effectively optimize the nerve function and suppress the systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.关键词
高血压脑出血/早期肠内营养干预/神经功能/全身氧化应激/炎症反应Key words
Hypertensive cerebral hemorrhage/Early enteral nutrition intervention/Nerve function/Systemic oxida-tive stress/Inflammatory response分类
医药卫生引用本文复制引用
高元凤..早期肠内营养干预对高血压脑出血患者神经功能、全身氧化应激及炎症反应的影响[J].海南医学院学报,2017,23(20):2862-2865,2869,5.基金项目
四川省科技局课题项目(20153625)This study was supported by Project of Science and Technology Bureau of Sichuan Province(20153625). （20153625）
