海南医学院学报2017，Vol.23Issue(20)：2877-2879,2883,4.DOI:10.13210/j.cnki.jhmu.20171009.006
浓缩生长因子联合引导骨再生术对重度牙周炎患者细胞增殖、骨吸收的影响
Effect of concentrated growth factor combined with guided bone regeneration on cell prolif-eration and bone resorption in patients with severe periodontitis
摘要
Abstract
Objective:To study the effect of concentrated growth factor(CGF)combined with guided bone regeneration on cell proliferation and bone resorption in patients with severe periodontitis.Methods:Patients with severe periodontitis who were treated in Stomatology Department of Shenmu Hospital between May 2014 and February 2017 were selected as the re-search subjects and randomly divided into two groups,surgery + CGF group received concentrated growth factor combined with guided bone regeneration,and pure surgery group received guided bone regeneration.The contents of inflammatory re-sponse,cell proliferation and bone resorption markers in gingival crevicular fluid were determined 1 week after treatment.Re-sults:1 week after treatment,HMGB1,ICAM1,E-selectin,Smac,FasL,Caspase-8,Caspase-9,Caspase-3,RANKL and NTX contents in gingival crevicular fluid of surgery + CGF group were significantly lower than those of pure surgery group while PD-L1,hBD-3,Wnt3a,BGP and OPG contents were significantly lower than those of pure surgery group.Conclusion:Concentrated growth factor combined with guided bone regeneration for severe periodontitis can inhibit inflammatory response, apoptosis and bone resorption,which is beneficial to the reconstruction of periodontal tissue.关键词
牙周炎/引导骨再生术/浓缩生长因子/细胞增殖/骨吸收Key words
Periodontitis/guided bone regeneration/concentrated growth factor/cell proliferation/bone resorption分类
医药卫生引用本文复制引用
高强..浓缩生长因子联合引导骨再生术对重度牙周炎患者细胞增殖、骨吸收的影响[J].海南医学院学报,2017,23(20):2877-2879,2883,4.基金项目
陕西省科技厅攻关项目(2012K16-06-02)It is supported by Key Project of Science and Technology Department of Shaanxi Province(2012K16-06-02)． （2012K16-06-02）
