海南医学院学报2017，Vol.23Issue(20)：2884-2886,2890,4.DOI:10.13210/j.cnki.jhmu.20170926.018
病理性瘢痕组织中TSG-6基因表达与细胞凋亡、胶原代谢的相关性研究
The correlation of TSG-6 expression with apoptosis and collagen metabolism in pathological scar tissue
摘要
Abstract
Objective:To study the correlation of tumor necrosis factor-α stimulated gene-6(TSG-6)expression with apoptosis and collagen metabolism in pathological scar tissue.Methods:Surgically removed pathological scar tissue and the nor-mal skin tissue removed due to extremity trauma in Sichuan Provincial People's Hospital between June 2014 and February 2017 were selected to detect the mRNA expression of TSG-6 as well as the protein levels of apoptosis genes and collagen metabolism indexes.Results:TSG-6 mRNA expression as well as Smac,p53,Cyt-C,IGF-1 and bFGF protein levels in pathological scar tissue was significantly lower than those in normal skin tissue while Livin,PCNA,Col-I,Col-III and TGF-β1 protein levels were significantly higher than those in normal skin tissue;Livin,PCNA,Col-I,Col-III and TGF-β1 protein levels in pathologi-cal scar tissue with higher TSG-6 expression were lower than those in pathological scar tissue with lower TSG-6 expression while Smac,p53,Cyt-C,IGF-1 and bFGF protein levels were significantly higher than those in pathological scar tissue with lower TSG-6 expression.Conclusion:The low expression of TSG-6 in pathological scar tissue can inhibit apoptosis and promote collagen anabolism to accelerate scar formation.关键词
病理性瘢痕/肿瘤坏死因子α刺激基因-6/凋亡/胶原Key words
Pathological scar/Tumor necrosis factor-α stimulated gene-6/Apoptosis/Collagen分类
医药卫生引用本文复制引用
卫东,杜丽萍,张家建..病理性瘢痕组织中TSG-6基因表达与细胞凋亡、胶原代谢的相关性研究[J].海南医学院学报,2017,23(20):2884-2886,2890,4.基金项目
成都市惠民技术研发项目(2014-HM01-00274-SF)This study was supported by Technology Research Project for Benefiting People of Chengdu City(2014-HM01-00274-SF) （2014-HM01-00274-SF）
