海南医学院学报2017，Vol.23Issue(22)：3058-3061,4.DOI:10.13210/j.cnki.jhmu.20171127.005
早期他汀类药物治疗联合静脉溶栓对急性脑梗死患者神经功能及细胞因子分泌的影响
Effects of early statins combined with intravenous thrombolysis on nerve function and cyto-kine secretion in patients with acute cerebral infarction
摘要
Abstract
Objective:To investigate the effects of early statins combined with intravenous thrombolysis on nerve func-tion and cytokine secretion in patients with acute cerebral infarction. Methods:21O patients with acute cerebral infarction who were treated in the hospital between September 2O15 and March 2O17 were divided into control group(n= 1O5) and statin group(n=1O5)by random number table. Control group received intravenous thrombolysis therapy,and statin group received early statins combined with intravenous thrombolysis therapy. The differences in serum levels of nerve function indicators,adi-pocytokines and oxidative stress indexes were compared between the two groups immediately after admission and after treat-ment. Results:Before treatment,the differences in serum levels of nerve function indexes,adipocytokines and oxidative stress indexes were not statistically significant between the two groups. After treatment,serum nerve function index S1OOB level of statin group was lower than that of control group whereas BDNF level was higher than that of control group;serum adipocyto-kine APN level was higher than that of control group while Resistin and Visfatin levels were lower than those of control group;serum oxidative stress indexes AOPPs and LHP levels were lower than those of control group whereas SOD and T-AOC levels were higher than those of control group. Conclusion:Early statins combined with intravenous thrombolysis can effectively im-prove the nerve function of patients with acute cerebral infarction,coordinate the secretion of a variety of cytokines and inhibit the activation of oxidative stress response.关键词
急性脑梗死/他汀类药物/神经功能/脂肪细胞因子/氧化应激Key words
Acute cerebral infarction/Statins/Nerve function/Adipocytokines/Oxidative stress分类
医药卫生引用本文复制引用
李欣慰..早期他汀类药物治疗联合静脉溶栓对急性脑梗死患者神经功能及细胞因子分泌的影响[J].海南医学院学报,2017,23(22):3058-3061,4.基金项目
2015年湖北省教育厅科学研究计划资助项目(D20151801) It is supported by Scientific Research Planning Fund of Hubei Provincial Education Department in 2015(D20151801). （D20151801）
