海南医学院学报2017，Vol.23Issue(22)：3077-3080,4.DOI:10.13210/j.cnki.jhmu.20171201.004
盐酸纳洛酮对COPD伴呼吸衰竭患者肺功能、血气变化及炎症因子的影响
Effects of naloxone hydrochloride on spulmonary function,blood gas changes and inflamma-tory factors in patients with COPD combined with respiratory failure
摘要
Abstract
Objective:To investigate the effects of naloxone hydrochloride on pulmonary function,blood gas changes and inflammatory factors in patients with COPD combined with respiratory failure.Methods:According to random data table method,8O cases of COPD combined with respiratory failure were randomly divided into the control group(n=4O)and obser-vation group(n=4O),patients in the control group were treated with noninvasive positive pressure ventilation on the basis of routine symptomatic treatment,on the basis of the treatment of the control group,the observation group received naloxone hydrochloride theraphy.The levels of spulmonary function,blood gas changes and inflammatory factors were compared in two groups before and after treatment.Results:The levels of serum FEV1,FVC,PEF,PaCO2,PaO2,PaO2/FiO2,TNF-α and PCT in the two groups before treatment were not statistically significant(P>O.O5).After treatment,the levels of FEV1, FVC,PEF in the two groups were(7O.O1 ± O.36)%,(2.16 ± O.41)L,(2.98 ± O.45)L/s and(81.71 ± O.53)%,(3.65 ± O.55) L,(4.36 ± O.43)L/s,which were significantly higher than those in the same group before treatment(P<O.O5),and the ob-servation group levels were significantly higher than those in the control group;the levels of PaCO2,PaO2and PaO2/FiO2in the two groups were(59.62 ± 6.47)mmHg,(65.53 ± 7.36)mmHg,(323.89 ± 1O.47)and(46.59 ± 6.64)mmHg,(73.65 ± 8. 26)mmHg,(398.64 ± 14.O6),compared with the same group before treatment,PaCO2levels were significantly lower in both groups(P<O.O5),and the observation group was significantly lower than the control group,PaO2,PaO2/FiO2levels were significantly higher in both groups(P<O.O5),and the observation group was significantly higher than the control group;the levels of TNF-α,PCT in the two groups were(23.28 ± 4.53)pg/mL,(5.22 ± 2.13)ng/mL and(16.61 ± 4.12)pg/mL,(2.O7 ± 1.21)ng/mL,which were significantly lower than those in the same group before treatment(P<O.O5),and the observation group levels were significantly lower than those in the control group;the above differences were statistically significant(P<O.O5).Conclusion:Treatment of COPD with respiratory failure by naloxone hydrochloride,can effectively reduce the level of in-flammatory factors,and improved lung function and blood gas levels,which has important clinical value.关键词
盐酸纳洛酮/COPD伴呼吸衰竭/肺功能/血气变化/炎症因子Key words
Naloxone hydrochloride/COPD combined with respiratory failure/Spulmonary function/Blood gas chan-ges/Inflammatory factors分类
医药卫生引用本文复制引用
吴娟,王军,张毅..盐酸纳洛酮对COPD伴呼吸衰竭患者肺功能、血气变化及炎症因子的影响[J].海南医学院学报,2017,23(22):3077-3080,4.基金项目
四川省技术创新资助项目(2015EF14338) This study was supported by Technical Innovation Funded Project in Sichuan Province(2015EF14338) （2015EF14338）
