海南医学院学报2017，Vol.23Issue(22)：3089-3091,3095,4.DOI:10.13210/j.cnki.jhmu.20171025.005
术前多西他赛联合S-1化疗对进展期胃癌病灶内癌基因表达的影响
Effect of the preoperative docetaxel combined with S-1 chemotherapy on the oncogene ex-pression in advanced gastric cancer lesion
摘要
Abstract
Objective:To study the effect of the preoperative docetaxel combined with Tegafur Gimeracil Oteracil Potas-sium(S-1)chemotherapy on the oncogene expression in advanced gastric cancer lesion.Methods:Patients who were diagnosed with advanced gastric cancer in Yidu the First People's Hospital between April 2O14 and January 2O17 were selected as the re-search subjects and randomly divided into two groups,the DS group received preoperative docetaxel combined with S-1 neoad-juvant chemotherapy,and the control group accepted routine preoperative intervention.Surgically removed gastric cancer speci-mens were collected to determine the mRNA expression of tumor suppressor genes,proto-oncogene and invasion genes.Re-sults:ING5,p16,Noxa and Bax mRNA expression in gastric cancer lesions of DS group were significantly higher than those of control group while PTP1B,CDC25B,UHRF1,HOXB7,c-myc,GOLPH3,Vav2,ELMO,ZEB1 and Rho-A mRNA expres-sion were significantly lower than those of control group.Conclusion:Preoperative docetaxel combined with S-1 chemotherapy for advanced gastric cancer can increase the expression of tumor suppressor genes and inhibit the expression of proto-oncogene and aggression genes.关键词
进展期胃癌/多西他赛/替吉奥/癌基因Key words
Advanced gastric cancer/docetaxel/Tegafur Gimeracil Oteracil Potassium/oncogene分类
医药卫生引用本文复制引用
贲鄂宜,熊家兵..术前多西他赛联合S-1化疗对进展期胃癌病灶内癌基因表达的影响[J].海南医学院学报,2017,23(22):3089-3091,3095,4.基金项目
三峡大学培优基金(A2011-302-38) The China Three Gorges University Pei you fund(A2011-302-38) （A2011-302-38）
