海南医学院学报2017，Vol.23Issue(22)：3146-3149,4.DOI:10.13210/j.cnki.jhmu.20171120.027
感染性肺炎患儿炎症反应及免疫功能相关指标水平变化及意义
Changes and significance of inflammatory reaction and immune function in children with in-fectious pneumonia
摘要
Abstract
Objective:To investigate the changes of inflammatory factors and immune function indexes in children with infectious pneumonia,to analyze the relationship between the level of indicators and the severity of the disease.Methods:16O children with infectious pneumonia were selected as the observation group included bacterial pneumonia group(n=98),myco-plasma pneumonia group(n=32)and viral pneumonia group(n=3O),according to the severity of the disease,they were di-vided into mild group(n=1O5)and severe group(n=55),at the same time 1OO cases of healthy children in the same period were selected as control group,the levels of inflammatory factors and the indexes of immune function were compared between the groups and different courses of disease.Results:Compared with the control group,the levels of hs-CRP and PCT in the ob-servation group were significantly increased,and in the observation group,the bacterial pneumonia group of hs-CRP and PCT levels were significantly higher than those in mycoplasma pneumonia group and viral pneumonia group,compared with the viral pneumonia group hs-CRP level,the level in the mycoplasma pneumonia group was significantly increased(P< O.O5);The comparison of immune function index,the observation group CD3+,CD4+and CD4+/CD8+levels[(66.32 ± 8.61)%,(36.51 ± 6.26),(1.21 ± O.29)]were significantly lower than those of the control group,the level of CD8+(26.34 ± 5.11)% was sig-nificantly higher than the control group(22.75 ± 3.88)%(P<O.O5),but the levels of CD3+,CD4+,CD8+and CD4+/CD8+in each group of the observation group were not statistically significant(P>O.O5);The severe group hs-CRP,PCT and CD8+levels were significantly higher than the mild group,and the levels of CD3+,CD4+and CD4+/CD8+were significantly de-creased(P<O.O5).Conclusion:There is a marked inflammatory response and abnormal cellular immune function in children with infectious pneumonia,and its level detection is of great value in the diagnosis of disease and the assessment of the severity of the disease.关键词
感染性肺炎/炎症反应/免疫功能/检测及意义Key words
Infectious pneumonia/Inflammatory reaction/Immune function/Detection and significance分类
医药卫生引用本文复制引用
李雄海,王晓琴,梁骑..感染性肺炎患儿炎症反应及免疫功能相关指标水平变化及意义[J].海南医学院学报,2017,23(22):3146-3149,4.基金项目
四川省科技创新苗子工程(2017057) This study was supported by Science and Technology Innovation Talent Project of Sichuan Province(2017057). （2017057）
