海南医学院学报2017，Vol.23Issue(22)：3161-3164,3168,5.DOI:10.13210/j.cnki.jhmu.20171120.008
巴曲酶联合银杏达莫注射液对突发性耳聋患者血流动力学、凝血功能、纤维蛋白溶解功能及相关因子水平的影响
Effect of batroxobin combine with ginkgo-damole injection on hemodynamics,coagulation function,fibrinolytic function and related factors in patients with sudden deafness
摘要
Abstract
Objective:To study the effects of combined use of drugs on hemodynamics,coagulation function,fibrino-lytic function and related factors.Methods:Total of 94 patients with sudden deafness in our hospital were selected,which were divided into control group and observation group randomly,with 47 cases in each group.All patients were given 1O BU batrox-obin injection intravenous drip after admission every other day;And the patients of observation group were given intravenous drip of 3O mL ginkgo-damole injection,1 times a day.The hemodynamics,coagulation function,fibrinolytic function and relat-ed factors were detected and compared between the two groups before and after treatment.Results:Before treatment,there was no statistical difference in hemodynamics,coagulation function,fibrinolytic function and related factors between the two groups (P>O.O5);After treatment,the levels of WBV and PV in the control group was(5.21 ± O.58)mPa/s and(1.78 ± O.32)mPa/s,and the observation group was(4.13 ± O.47)mPa/s and(1.31 ± O.26)mPa/s,compared with the same group before treat-ment,there were statistical difference(P<O.O5),and there was also statistical difference between the two groups(P<O.O5);the levels of PT,APTT,TT and PF was(19.22 ± 3.98)s,(43.57 ± 9.88)s,(15.64 ± 3.27)s and(58.22 ± 1O.58)μg/L,and the observation group was(23.97 ± 4.82)s,(52.49 ± 1O.38)s,(2O.59 ± 4.15)s and(41.O3 ± 8.46)μg/L,compared with the same group before treatment,there were statistical difference(P<O.O5),and there was also statistical difference between the two groups(P<O.O5);The levels of Fib,D-dimer and FDP was(4.52 ± O.93)g/L,(6.53 ± 1.88)mg/L and(8.17 ± 2.34) μg/mL,and the observation group was(3.13 ± O.75)g/L,(9.75 ± 2.14) mg/L,(13.52 ± 2.58)μg/mL,compared with the same group before treatment,there were statistical difference(P<O.O5),and there was also statistical difference between the two groups(P<O.O5);The serum levels of ET,NO and SOD was(66.92 ± 5.87)ρg/mL,(48.75 ± 7.61)μmol/L,(95.O1 ± 12.38)NU/mL,and the observation group was(63.97 ± 5.24)ρg/mL,(43.11 ± 6.83)μmol/L,(1O4.79 ± 13.15)NU/mL, compared with the same group before treatment,there were statistical difference(P< O.O5),and there was also statistical difference between the two groups(P< O.O5).Conclusion The treatment of patients with sudden deafness using batroxobin combine with ginkgo-damole injection,can improve the hemodynamics,coagulation function,fibrinolytic function of patients, decrease the serum levels of ET and NO,improve the levels of SOD,the effect is curative,it's worthy of clinical application.关键词
突发性耳聋/巴曲酶/银杏达莫注射液Key words
Sudden deafness/Batroxobin/Ginkgo-damole injection分类
医药卫生引用本文复制引用
徐翔,何庆文,肖才文,辛鹏..巴曲酶联合银杏达莫注射液对突发性耳聋患者血流动力学、凝血功能、纤维蛋白溶解功能及相关因子水平的影响[J].海南医学院学报,2017,23(22):3161-3164,3168,5.基金项目
湖北省卫生厅计划项目(2016-18) This project is funded by Planning Project of Health Department of Hubei Province(2016-18) （2016-18）
