海南医学院学报2017，Vol.23Issue(22)：3169-3172,4.DOI:10.13210/j.cnki.jhmu.20171127.008
七氟醚+丙泊酚+瑞芬太尼静吸复合全麻对脑出血患者开颅手术后脑损伤及氧化应激反应的影响
Effects of sevoflurane + propofol + remifentanil intravenous inhalational anesthesia on brain injury and oxidative stress response in patients with cerebral hemorrhage after craniot-omy
摘要
Abstract
Objective:To study the effects of sevoflurane + propofol + remifentanil intravenous inhalational anesthesia on brain injury and oxidative stress response in patients with cerebral hemorrhage after craniotomy. Methods:Patients with cerebral hemorrhage who received craniotomy in Chongzhou People's Hospital in Sichuan Province between July 2O14 and Feb-ruary 2O17 were selected and randomly divided into two groups,Sev group received sevoflurane + propofol + remifentanil an-esthesia,and control group received propofol + remifentanil anesthesia. The brain injury indexes and oxidative stress indexes in serum and peripheral blood were measured 12 hours and 24 hours after surgery. Results:12 hours and 24 hours after surger-y,serum Hep,NSE,S1OOβ,Asp,HA,MMP9,OPN,ICAM-1,Cor and MDA levels as well as peripheral blood Nrf-2 and TRX mRNA expression of Sev group were greatly lower than those of control group whereas serum SOD and T-AOC levels were greatly higher than those of control group. Conclusion:sevoflurane + propofol + remifentanil intravenous inhalational anesthesia can reduce the brain injury and oxidative stress in patients with cerebral hemorrhage after craniotomy.关键词
脑出血/七氟醚/脑损伤/氧化应激反应Key words
Cerebral hemorrhage/Sevoflurane/Brain injury/Oxidative stress分类
医药卫生引用本文复制引用
雷雨..七氟醚+丙泊酚+瑞芬太尼静吸复合全麻对脑出血患者开颅手术后脑损伤及氧化应激反应的影响[J].海南医学院学报,2017,23(22):3169-3172,4.基金项目
四川省崇州市科技局项目(s201631) It is supported by Science and Technology Bureau Project of Chongzhou City in Sichuan Province(s201631). （s201631）
