海南医学院学报2017，Vol.23Issue(23)：3207-3210,4.DOI:10.13210/j.cnki.jhmu.20171120.013
糖尿病合并冠心病患者血清Hcy、UA含量与冠脉斑块性质变化的相关性研究
The correlation of serum Hcy and UA contents with coronary plaque property changes in dia-betic patients with coronary heart disease
摘要
Abstract
Objective:To study the correlation of serum Hcy and UA contents with coronary plaque property changes in diabetic patients with coronary heart disease.Methods:Patients who were diagnosed with type 2 diabetes mellitus in Dongguan Branch of Yan'an University Affiliated Hospital between May 2013 and June 2017 were selected and divided into the CHD+DM group who were complicated by coronary heart disease and the DM group who were not complicated by coronary heart dis-ease according to the results of coronary CTA ,and the healthy subjects who received physical examination in Dongguan Branch of Yan'an University Affiliated Hospital during the same period were selected as control group .The contents of homocysteine (Hcy) ,uric acid (UA) ,platelet activation indexes and protease indexes in serum were measured .Results :Serum Hcy ,UA ,sSema4D ,sP-selectin ,sE-selectin ,MMP1 ,MMP3 ,CatK and ADAMTS4 contents of DM group and CHD + DM group were greatly higher than those of control group whereas Klotho and TIMP2 contents were greatly lower than those of control group ;serum Hcy ,UA ,sSema4D ,sP-selectin ,sE-selectin ,MMP1 ,MMP3 ,CatK and ADAMTS4 contents of CHD + DM group were greatly higher than those of DM group whereas Klotho and TIMP2 contents were greatly lower than those of DM group ;serum sSema4D ,sP-selectin ,sE-selectin ,MMP1 ,MMP3 ,CatK and ADAMTS4 contents of CHD + DM group were positively correlated with Hcy and UA contents while Klotho and TIMP2 contents were negatively correlated with Hcy and UA contents .Conclusions :The abnormal increase of serum Hcy and UA contents in diabetic patients with coronary heart disease can promote the activation and aggregation of platelet ,the degradation of plaque fibrous cap and the decrease of plaque stability .关键词
糖尿病/冠心病/同型半胱氨酸/尿酸/血小板活化/蛋白酶Key words
Diabetes/Coronary heart disease/Homocysteine/Uric acid/Platelet activation/Protease分类
医药卫生引用本文复制引用
汪丽丽,郝春举,宋小英..糖尿病合并冠心病患者血清Hcy、UA含量与冠脉斑块性质变化的相关性研究[J].海南医学院学报,2017,23(23):3207-3210,4.基金项目
延安市科学技术研究发展计划项目(2012ks—17)This project is funded by Scientific and Technological Research Development Planning Project of Yan'an City(2012ks-17) （2012ks—17）
