海南医学院学报2017，Vol.23Issue(23)：3219-3222,4.DOI:10.13210/j.cnki.jhmu.20171127.011
不同核苷类似物对慢性乙肝患者肝纤维化及外周血树突状细胞功能的影响
Effect of different nucleoside analogues on liver fibrosis and peripheral blood dendritic cell function of patients with chronic hepatitis B
摘要
Abstract
Objective:To study the effect of different nucleoside analogues on liver fibrosis and peripheral blood den-dritic cell function of patients with chronic hepatitis B. Methods:Patients with chronic hepatitis B who received antiviral thera-py in Infectious Diseases Hospital of Shanghai Huangpu District between April 2014 and October 2016 were selected as the re-search subjects and divided into 3 groups,group A received entecavir therapy,group B received adefovir dipivoxil therapy and group C received lamivudine therapy. 24 weeks and 48 weeks after treatment,the levels of liver fibrosis indexes in serum as well the levels of DC and the expression of surface markers in peripheral blood of the three groups were measured respectively. Results:After treatment,serum hyaluronic acid(HA),procollagen III(PC-III),laminin(LN)and collagen type IV(C-IV) levels of all groups were significantly lower than those before treatment,and the number of myeloid DC(mDC)and plasmacy-toid DC(pDC)in peripheral blood as well as the expression levels of DC surface molecules CD 80,CD86,CD1α and HLA-DR in peripheral blood were significantly higher than those before treatment. After treatment,the serum levels of HA,PC-III, LN and C-IV in group A were significantly lower than those in group B and C,and the number of mDC and pDC in peripheral blood as well as the expression of DC surface molecules CD80,CD86,CD1α and HLA-DR in peripheral blood were significantly higher than those in group B and C. Conclusion :Antiviral therapy by nucleoside analogues can effectively inhibit liver fibrosis and improve peripheral blood DC function in patients with chronic hepatitis B ,and Entecavir function is better than that of adefovir dipivoxil and lamivudine.关键词
慢性乙型病毒性肝炎/肝纤维化/核苷类似物/树突状细胞Key words
chronic hepatitis B/liver fibrosis/nucleoside analogue/dendritic cell分类
医药卫生引用本文复制引用
冯晓霞,梁海林,聂苑霞..不同核苷类似物对慢性乙肝患者肝纤维化及外周血树突状细胞功能的影响[J].海南医学院学报,2017,23(23):3219-3222,4.基金项目
上海市黄浦区卫计委科技项目(HKW201551)This study was supported by Shanghai Huangpu District Health and Family Planning Commission(Grant No. HKW201551) （HKW201551）
