海南医学院学报2017，Vol.23Issue(23)：3263-3266,4.
神经母细胞瘤中KLF4、UBE2C表达水平与细胞黏附、迁移的相关性研究
The correlation of KLF4 and UBE2C expression levels in neuroblastoma with cell adhesion and migration
摘要
Abstract
Objective:To study the correlation of KLF4 and UBE2C expression levels in neuroblastoma with cell adhe-sion and migration.Methods:56 children who were diagnosed with neuroblastoma in the Central Hospital of Enshi Autonomous Prefecture between May 2014 and February 2017 were selected as the NB group of the study,and the lesion tissue was collect-ed;38 children who were treated in the Central Hospital of Enshi Autonomous Prefecture due to serious hydronephrosis during the same period were selected as the control group of the study,and the normal adrenal gland tissue was collected.The mRNA expression and protein expression of KLF4 and UBE2C as well as the protein expression of cell adhesion molecules and migra-tion molecules in clinical tissue samples were determined.Results:The mRNA expression and protein expression of KLF4 in neuroblastoma tissue of NB group were greatly lower than those of control group whereas the mRNA expression and protein expression of UBE2C were greatly higher than those of control group;PDLIM1,AMF,GPx1,L1CAM,Nrg1,RANK, RANKL,Inβ1,MTA1 and MMP9 protein expression in neuroblastoma tissue of NB group were greatly higher than those of control group,negatively correlated with the protein expression KLF4,and positively correlated with the protein expression of UBE2C.Conclusions:The low expression of KLF4 and the high expression of UBE2C in neuroblastoma can promote the adhe-sion and migration of tumor cells.关键词
神经母细胞瘤/Kruppel样因子4/泛素偶联酶2C/黏附/迁移Key words
Neuroblastoma/Kruppel-like factor 4/Ubiquitin-conjugating enzyme 2C/Adhesion/Migration分类
医药卫生引用本文复制引用
张弢,毛惠林,冯力..神经母细胞瘤中KLF4、UBE2C表达水平与细胞黏附、迁移的相关性研究[J].海南医学院学报,2017,23(23):3263-3266,4.基金项目
恩施州科技项目(160825)This study was supported by Science and Technology Project of Enshi Tujia and Miao Autonomous Prefecture(160825). （160825）
