海南医学院学报2017，Vol.23Issue(23)：3271-3274,4.DOI:10.13210/j.cnki.jhmu.20171120.005
西替利嗪口服联合布地奈德吸入对小儿哮喘急性发作过程中免疫炎症反应的影响
Effects of oral cetirizine combined with budesonide inhalation on immune inflammatory re-sponse in children with acute asthma attack
摘要
Abstract
Objective:To study the effects of oral cetirizine combined with budesonide inhalation on immune inflamma-tory response in children with acute asthma attack.Methods:Children with acute asthma attack who were treated in Beijing Lu-he Hospital Affiliated to Capital Medical University between April 2014 and February 2017 were selected and randomly divided into two groups,observation group received oral cetirizine combined with budesonide inhalation therapy,and control group re-ceived budesonide inhalation therapy.The contents of CD4+T cell subsets and the expression of immune transcription factors in peripheral blood as well as the contents of CD4+T cytokines and inflammatory mediators in serum were measured after 1 week of treatment.Results:After 1 week of treatment,Th1 and Treg contents as well as BCL11B,STAT4 and SOCS3 mRNA ex-pression in peripheral blood as well as IFN-γ and IL-10 contents in serum of observation group were greatly higher than those of control group while Th2,Th17 and Th22 contents as well as STAT1 and STAT3 mRNA expression in peripheral blood as well as IL-4,IL-17,IL-22,HMGB1,Periostin,Eotaxin and ADAM33 contents in serum were greatly lower than those of control group.Conclusions:Oral cetirizine combined with budesonide inhalation is more effective than budesonide inhalation a-lone to modulate the immune inflammatory response in children with acute asthma attack.关键词
支气管哮喘/西替利嗪/布地奈德/免疫应答/炎症反应Key words
Bronchial asthma/Cetirizine/budesonide/Immune response/Inflammatory response分类
医药卫生引用本文复制引用
孙妍..西替利嗪口服联合布地奈德吸入对小儿哮喘急性发作过程中免疫炎症反应的影响[J].海南医学院学报,2017,23(23):3271-3274,4.基金项目
北京市医疗卫生科技计划项目(CXPY201606)This project is funded by Medical Health Science and Technology Planning Project of Beijing City(CXPY201606) （CXPY201606）
