海南医学院学报2017，Vol.23Issue(23)：3318-3321,3326,5.DOI:10.13210/j.cnki.jhmu.20171120.023
CTA对后循环脑梗死患者椎基底动脉狭窄的评估价值及其与血清生化指标的相关性
The evaluation value of CTA for vertebrobasilar artery stenosis in patients with posterior cir-culation cerebral infarction and its correlation with serum biochemical indexes
摘要
Abstract
Objective:To study the evaluation value of CTA for vertebrobasilar artery stenosis in patients with posterior circulation cerebral infarction and its correlation with serum biochemical indexes.Methods:148 patients who were treated in Maanshan Shiqiye Hospital between June 2014 and February 2017 due to vertebrobasilar artery stenosis were selected as the re-search subjects and divided into cerebral infarction group and transient ischemic attack(TIA)group according to the imageo-logical examination.CTA was used to evaluate vertebrobasilar atherosclerotic plaque properties,and enzyme-linked immu-nosorbent assay kit was used to determine the levels of nerve injury markers,inflammatory response-related molecules and plaque property-related protease molecules.Results:The positive rate of posterior circulation plaque in cerebral infarction group was obviously higher than that in TIA group,and the positive rate of unstable plaque,fibrous plaque and calcified plaque were higher than those in TIA group;serum NSE,S100B,UCH-L1,GFAP,ICAM-1,VCAM-1,PECAM-1,VE-cadherin,YKL-40,CatS,MMP9,MMP10 and ADAMTS12 levels of cerebral infarction group of patients with unstable plaque,fibrous plaque and calcified plaque were all higher than those of TIA group;serum NSE,S100B,UCH-L1,GFAP,ICAM-1,VCAM-1,PE-CAM-1,VE-cadherin,YKL-40,CatS,MMP9,MMP10 and ADAMTS12 levels of cerebral infarction group of patients with unstable plaque and fibrous plaque were all higher than those of patients with calcified plaque,and serum NSE,S100B,UCH-L1,GFAP,ICAM-1,VCAM-1,PECAM-1,VE-cadherin,YKL-40,CatS,MMP9,MMP10 and ADAMTS12 levels of cere-bral infarction group of patients with unstable plaque were all higher than those of patients with fibrous plaque.Conclusions:CTA can accurately assess the property of vertebrobasilar atherosclerotic plaque in patients with posterior circulation cerebral infarction and is closely related to the degree of nerve injury and the change of plaque property.关键词
后循环脑梗死/CT血管造影/椎基底动脉狭窄/动脉粥样硬化Key words
Posterior circulation cerebral infarction/CT angiography/Vertebrobasilar artery stenosis/Atherosclerosis分类
医药卫生引用本文复制引用
田德名,朱玉胜,周逢春,张扬..CTA对后循环脑梗死患者椎基底动脉狭窄的评估价值及其与血清生化指标的相关性[J].海南医学院学报,2017,23(23):3318-3321,3326,5.基金项目
安徽省自然科学基金(1308085M H158)This study was supported by Natural Science Foundation of Anhui Province(1308085MH158). （1308085M H158）
