海南医学院学报2017，Vol.23Issue(23)：3322-3326,5.DOI:10.13210/j.cnki.jhmu.20171120.018
普罗布考辅助视网膜光凝治疗对增殖早期糖尿病视网膜病变的视觉功能及血清生化指标的影响
The influence of probucol-assisted retinal photocoagulation therapy on the visual perform-ance and serum biochemical indexes in patients with early proliferative diabetic retinopathy
摘要
Abstract
Objective:To explore the influence of probucol-assisted retinal photocoagulation therapy on the visual per-formance and serum biochemical indexes in patients with early proliferative diabetic retinopathy.Methods:170 patients with ear-ly proliferative DR who were treated in the hospital between December 2014 and May 2017 were retrospectively analyzed and divided into the control group(n=107)who received retinal photocoagulation therapy alone and the probucol group(n=63) who received probucol-assisted retinal photocoagulation therapy.The differences in the contents of visual performance indexes as well as serum angiogenesis indexes,inflammatory mediators and oxidative stress indexes were compared between the two groups before treatment and after 6 weeks of treatment.Results:Before treatment,the differences in the levels of visual per-formance indexes as well as serum contents of angiogenesis indexes,inflammatory mediators and oxidative stress indexes were not statistically significant between the two groups of patients.After 6 weeks of treatment,mean vision,30°visual acuity and 30°~60°visual acuity of probucol group were higher than those of control group;serum angiogenesis indexes HIF-1,VEGF and Ang-2 contents were lower than those of control group;serum inflammatory mediators ICAM-1,IL-2,IL-23 and TNF-α contents were lower than those of control group;serum oxidative stress index MDA content was lower than that of control group whereas TAC content was higher than that of control group.Conclusions:Probucol-assisted retinal photocoagulation therapy can effectively optimize the visual performance and promote the homeostasis recovery in patients with early proliferative diabetic retinopathy.关键词
增殖早期糖尿病视网膜病变/普罗布考/视网膜光凝/视觉功能Key words
Early proliferative diabetic retinopathy/Probucol/Retinal photocoagulation/Visual performance分类
医药卫生引用本文复制引用
文晓霞,谭德文,方腾,李红军..普罗布考辅助视网膜光凝治疗对增殖早期糖尿病视网膜病变的视觉功能及血清生化指标的影响[J].海南医学院学报,2017,23(23):3322-3326,5.基金项目
重庆市卫生计生委医学科研项目(2017ZBXM063)This study was supported by Medical Research Project of Chongqing Health and Family Planning Commission(2017ZBXM063) （2017ZBXM063）
